Caspase recruitment domain-containing protein 8

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Caspase recruitment domain family, member 8
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CARD8 ; CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN
External IDs OMIM609051 HomoloGene136365 GeneCards: CARD8 Gene
RNA expression pattern
PBB GE CARD8 204950 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22900 n/a
Ensembl ENSG00000105483 n/a
UniProt Q9Y2G2 n/a
RefSeq (mRNA) NM_001184900 n/a
RefSeq (protein) NP_001171829 n/a
Location (UCSC) Chr 19:
48.68 – 48.76 Mb
n/a
PubMed search [1] n/a

Caspase recruitment domain-containing protein 8 is an protein that in humans is encoded by the CARD8 gene.[1][2][3]

Function[edit]

Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NF-κB) in the context of apoptosis or inflammation, respectively.[3]

References[edit]

  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
  2. ^ Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC (Aug 2001). "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer". J Biol Chem 276 (34): 32220–9. doi:10.1074/jbc.M100433200. PMID 11408476. 
  3. ^ a b "Entrez Gene: CARD8 caspase recruitment domain family, member 8". 

Further reading[edit]