CB-13

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CB-13
CB-13 structure.png
Systematic (IUPAC) name
naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone
Clinical data
Legal status
?
Identifiers
CAS number 432047-72-8 YesY
ATC code ?
PubChem CID 9799417
Chemical data
Formula C26H24O2 
Mol. mass 368.467 g/mol
 YesY (what is this?)  (verify)

CB-13 (SAB-378)[1] is a cannabinoid drug, which acts as a potent agonist at both the CB1 and CB2 receptors, but has poor blood–brain barrier penetration, and so produces only peripheral effects at low doses, with symptoms of central effects such as catalepsy only appearing at much higher dose ranges. It has antihyperalgesic properties in animal studies,[2] and has progressed to preliminary human trials.[3]

See also[edit]

References[edit]

  1. ^ Cluny, N. L.; Keenan, C. M.; Duncan, M.; Fox, A.; Lutz, B.; Sharkey, K. A. (2010). "Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a Peripherally Restricted Cannabinoid CB1/CB2 Receptor Agonist, Inhibits Gastrointestinal Motility but Has No Effect on Experimental Colitis in Mice". Journal of Pharmacology and Experimental Therapeutics 334 (3): 973. doi:10.1124/jpet.110.169946. PMID 20571060.  edit
  2. ^ Dziadulewicz, E. K.; Bevan, S. J.; Brain, C. T.; Coote, P. R.; Culshaw, A. J.; Davis, A. J.; Edwards, L. J.; Fisher, A. J.; Fox, A. J.; Gentry, C.; Groarke, A.; Hart, T. W.; Huber, W.; James, I. F.; Kesingland, A.; La Vecchia, L.; Loong, Y.; Lyothier, I.; McNair, K.; O'Farrell, C.; Peacock, M.; Portmann, R.; Schopfer, U.; Yaqoob, M.; Zadrobilek, J. (2007). "Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone:  A Potent, Orally Bioavailable Human CB1/CB2Dual Agonist with Antihyperalgesic Properties and Restricted Central Nervous System Penetration". Journal of Medicinal Chemistry 50 (16): 3851–3856. doi:10.1021/jm070317a. PMID 17630726.  edit
  3. ^ Gardin A, Kucher K, Kiese B, Appel-Dingemanse S (April 2009). "Cannabinoid receptor agonist 13, a novel cannabinoid agonist: first in human pharmacokinetics and safety". Drug Metabolism and Disposition: the Biological Fate of Chemicals 37 (4): 827–33. doi:10.1124/dmd.108.024000. PMID 19144772.