CBLC

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Cbl proto-oncogene, E3 ubiquitin protein ligase C
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CBLC ; CBL-3; CBL-SL; RNF57
External IDs OMIM608453 MGI1931457 HomoloGene8108 GeneCards: CBLC Gene
RNA expression pattern
PBB GE CBLC 220638 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23624 80794
Ensembl ENSG00000142273 ENSMUSG00000040525
UniProt Q9ULV8 Q80XL1
RefSeq (mRNA) NM_001130852 NM_001161844
RefSeq (protein) NP_001124324 NP_001155316
Location (UCSC) Chr 19:
45.28 – 45.3 Mb
Chr 7:
19.78 – 19.8 Mb
PubMed search [1] [2]

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.[1][2][3]

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM][3]

Interactions[edit]

CBLC has been shown to interact with FYN[4] and Epidermal growth factor receptor.[2][5]

References[edit]

  1. ^ Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID 10362357. 
  2. ^ a b Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID 10571044. 
  3. ^ a b "Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c". 
  4. ^ Kim, M; Tezuka T; Suziki Y; Sugano S; Hirai M; Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene (NETHERLANDS) 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN 0378-1119. PMID 10571044. 
  5. ^ Keane, M M; Ettenberg S A; Nau M M; Banerjee P; Cuello M; Penninger J; Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene (ENGLAND) 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. ISSN 0950-9232. PMID 10362357. 

Further reading[edit]