CBX2 (gene)

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Chromobox homolog 2
Protein CBX2 PDB 2d9u.png
PDB rendering based on 2d9u.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CBX2 ; CDCA6; M33; SRXY5
External IDs OMIM602770 MGI88289 HomoloGene7256 GeneCards: CBX2 Gene
RNA expression pattern
PBB GE CBX2 215989 at tn.png
PBB GE CBX2 gnf1h00861 at tn.png
More reference expression data
Species Human Mouse
Entrez 84733 12416
Ensembl ENSG00000173894 ENSMUSG00000025577
UniProt Q14781 P30658
RefSeq (mRNA) NM_005189 NM_007623
RefSeq (protein) NP_005180 NP_031649
Location (UCSC) Chr 17:
77.75 – 77.76 Mb
Chr 11:
119.02 – 119.03 Mb
PubMed search [1] [2]

Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene.[1][2][3] According to a New Scientist article CBX2 controls human sex even more so than X/Y chromosomes.[4]


CBX2 (gene) has been shown to interact with RYBP.[5] It also interacts with the testis determining factor encoded by the SRY gene on the Y chromosome, as both proteins are necessary components of the male cascade.


  1. ^ Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071. 
  2. ^ Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology 34 (4 Suppl): 10–2; discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID 2477932. 
  3. ^ "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)". 
  4. ^ Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist, 2009-04-09. Retrieved on 2009-04-14.
  5. ^ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680. 

Further reading[edit]