CBX5 (gene)

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Chromobox homolog 5
Protein CBX5 PDB 3FDT.png
Rendering based on PDB 3FDT.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CBX5 ; HEL25; HP1; HP1A
External IDs OMIM604478 MGI109372 HomoloGene7257 GeneCards: CBX5 Gene
RNA expression pattern
PBB GE CBX5 209715 at tn.png
More reference expression data
Species Human Mouse
Entrez 23468 12419
Ensembl ENSG00000094916 ENSMUSG00000009575
UniProt P45973 Q61686
RefSeq (mRNA) NM_001127321 NM_001076789
RefSeq (protein) NP_001120793 NP_001070257
Location (UCSC) Chr 12:
54.62 – 54.67 Mb
Chr 15:
103.19 – 103.24 Mb
PubMed search [1] [2]

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.[1][2]

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM][2]


CBX5 (gene) has been shown to interact with HDAC9,[3] Ku70,[4] MIS12,[5] Lamin B receptor,[6] MBD1,[7][8] TAF4,[9] Histone deacetylase 5,[3] TRIM28,[10][11][12][13] HDAC4,[3] CBX3,[12] SMARCA4,[10] DNMT3B,[14] CHAF1A,[8][13] CBX1[12] and SUV39H1.[3][7][15]

See also[edit]


  1. ^ Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349. 
  2. ^ a b "Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)". 
  3. ^ a b c d Zhang, Chun Li; McKinsey Timothy A; Olson Eric N (October 2002). "Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation". Mol. Cell. Biol. (United States) 22 (20): 7302–12. doi:10.1128/MCB.22.20.7302-7312.2002. ISSN 0270-7306. PMC 139799. PMID 12242305. 
  4. ^ Song, K; Jung Y; Jung D; Lee I (March 2001). "Human Ku70 interacts with heterochromatin protein 1alpha". J. Biol. Chem. (United States) 276 (11): 8321–7. doi:10.1074/jbc.M008779200. ISSN 0021-9258. PMID 11112778. 
  5. ^ Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. (England) 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. 
  6. ^ Ye, Q; Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. (UNITED STATES) 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. ISSN 0021-9258. PMID 8663349. 
  7. ^ a b Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Tsuruzoe Shu; Shinkai Yoichi; Tachibana Makoto; Chiba Tsutomu; Nakao Mitsuyoshi (June 2003). "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression". J. Biol. Chem. (United States) 278 (26): 24132–8. doi:10.1074/jbc.M302283200. ISSN 0021-9258. PMID 12711603. 
  8. ^ a b Reese, Brian E; Bachman Kurtis E; Baylin Stephen B; Rountree Michael R (May 2003). "The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1". Mol. Cell. Biol. (United States) 23 (9): 3226–36. doi:10.1128/MCB.23.9.3226-3236.2003. ISSN 0270-7306. PMC 153189. PMID 12697822. 
  9. ^ Vassallo, Milo F; Tanese Naoko (April 2002). "Isoform-specific interaction of HP1 with human TAFII130". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (9): 5919–24. doi:10.1073/pnas.092025499. ISSN 0027-8424. PMC 122877. PMID 11959914. 
  10. ^ a b Nielsen, Anders Lade; Sanchez Cecilia; Ichinose Hiroshi; Cerviño Margarita; Lerouge Thierry; Chambon Pierre; Losson Régine (November 2002). "Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha". EMBO J. (England) 21 (21): 5797–806. doi:10.1093/emboj/cdf560. ISSN 0261-4189. PMC 131057. PMID 12411497. 
  11. ^ Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (September 2002). "Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction". J. Cell. Sci. (England) 115 (Pt 17): 3439–48. ISSN 0021-9533. PMID 12154074. 
  12. ^ a b c Nielsen, A L; Oulad-Abdelghani M; Ortiz J A; Remboutsika E; Chambon P; Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell (United States) 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697. 
  13. ^ a b Lechner, M S; Begg G E; Speicher D W; Rauscher F J (September 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. ISSN 0270-7306. PMC 86120. PMID 10938122. 
  14. ^ Lehnertz, Bernhard; Ueda Yoshihide, Derijck Alwin A H A, Braunschweig Ulrich, Perez-Burgos Laura, Kubicek Stefan, Chen Taiping, Li En, Jenuwein Thomas, Peters Antoine H F M (July 2003). "Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin". Curr. Biol. (England) 13 (14): 1192–200. doi:10.1016/S0960-9822(03)00432-9. ISSN 0960-9822. PMID 12867029. 
  15. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.