CBX7 (gene)

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Chromobox homolog 7 is a protein that in humans is encoded by the CBX7 gene.[1] The loss of CBX7 gene expression has been shown to correlate with a malignant form of thyroid cancer.[2]

Model organisms[edit]

Model organisms have been used in the study of CBX7 function. A conditional knockout mouse line, called Cbx7tm1a(KOMP)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[11][12][13] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty six tests were carried out and three significant phenotypes were reported. Homozygous mutant female adults showed a decreased response to stress-induced hyperthermia and had an increased red blood cell count. Animals of both sex had an integument phenotype when tail epidermis was examined.[7]


  1. ^ "Chromobox homolog 7". Retrieved 2011-12-06. 
  2. ^ Pallante, P.; Federico, A.; Berlingieri, M. T.; Bianco, M.; Ferraro, A.; Forzati, F.; Iaccarino, A.; Russo, M.; Pierantoni, G. M.; Leone, V.; Sacchetti, S.; Troncone, G.; Santoro, M.; Fusco, A. (2008). "Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer". Cancer Research 68 (16): 6770–6778. doi:10.1158/0008-5472.CAN-08-0695. PMID 18701502.  edit
  3. ^ "Body temperature data for Cbx7". Wellcome Trust Sanger Institute. 
  4. ^ "Haematology data for Cbx7". Wellcome Trust Sanger Institute. 
  5. ^ "Salmonella infection data for Cbx7". Wellcome Trust Sanger Institute. 
  6. ^ "Citrobacter infection data for Cbx7". Wellcome Trust Sanger Institute. 
  7. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  8. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  9. ^ "International Knockout Mouse Consortium". 
  10. ^ "Mouse Genome Informatics". 
  11. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  12. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  13. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  14. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]