CBY1

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Chibby homolog 1 (Drosophila)
Identifiers
Symbols CBY1 ; C22orf2; CBY; HS508I15A; PGEA1; PIGEA-14; PIGEA14; arb1
External IDs OMIM607757 MGI1920989 HomoloGene12514 GeneCards: CBY1 Gene
RNA expression pattern
PBB GE CBY1 203450 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25776 73739
Ensembl ENSG00000100211 ENSMUSG00000022428
UniProt Q9Y3M2 Q9D1C2
RefSeq (mRNA) NM_001002880 NM_028634
RefSeq (protein) NP_001002880 NP_082910
Location (UCSC) Chr 22:
39.05 – 39.07 Mb
Chr 15:
79.66 – 79.67 Mb
PubMed search [1] [2]

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.[1][2][3]

Function[edit]

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions[edit]

CBY1 has been shown to interact with Beta-catenin.[4]

References[edit]

  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699. 
  3. ^ a b "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)". 
  4. ^ Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206. 

Further reading[edit]