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Chibby homolog 1 (Drosophila)
Symbols CBY1 ; C22orf2; CBY; HS508I15A; PGEA1; PIGEA-14; PIGEA14; arb1
External IDs OMIM607757 MGI1920989 HomoloGene12514 GeneCards: CBY1 Gene
RNA expression pattern
PBB GE CBY1 203450 at tn.png
More reference expression data
Species Human Mouse
Entrez 25776 73739
Ensembl ENSG00000100211 ENSMUSG00000022428
UniProt Q9Y3M2 Q9D1C2
RefSeq (mRNA) NM_001002880 NM_028634
RefSeq (protein) NP_001002880 NP_082910
Location (UCSC) Chr 22:
39.05 – 39.07 Mb
Chr 15:
79.66 – 79.67 Mb
PubMed search [1] [2]

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.[1][2][3]


Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[3]


CBY1 has been shown to interact with Beta-catenin.[4]


  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699. 
  3. ^ a b "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)". 
  4. ^ Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206. 

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