CCBP2

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Chemokine binding protein 2
Identifiers
Symbols CCBP2 ; CCR10; CCR9; CMKBR9; D6; hD6
External IDs OMIM602648 MGI1891697 HomoloGene992 IUPHAR: CCPB2 GeneCards: CCBP2 Gene
RNA expression pattern
PBB GE CCBP2 206887 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1238 59289
Ensembl ENSG00000144648 ENSMUSG00000044534
UniProt O00590 O08707
RefSeq (mRNA) NM_001296 NM_001276719
RefSeq (protein) NP_001287 NP_001263648
Location (UCSC) Chr 3:
42.85 – 42.95 Mb
Chr 9:
121.9 – 121.91 Mb
PubMed search [1] [2]

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.[1][2][3]

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[3]

References[edit]

  1. ^ Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF (Dec 1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936. 
  2. ^ Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Jan 1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J Biol Chem 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404. 
  3. ^ a b "Entrez Gene: CCBP2 chemokine binding protein 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.