CCL17

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Chemokine (C-C motif) ligand 17

PDB rendering based on 1nr2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CCL17 ; A-152E5.3; ABCD-2; SCYA17; TARC
External IDs OMIM601520 MGI1329039 HomoloGene2246 GeneCards: CCL17 Gene
RNA expression pattern
PBB GE CCL17 207900 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6361 20295
Ensembl ENSG00000102970 ENSMUSG00000031780
UniProt Q92583 Q9R043
RefSeq (mRNA) NM_002987 NM_011332
RefSeq (protein) NP_002978 NP_035462
Location (UCSC) Chr 16:
57.44 – 57.45 Mb
Chr 8:
94.81 – 94.81 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells.[1] This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.[1][2] The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1.[3][4]

References[edit]

  1. ^ a b Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, Yoshie O (1996). "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector". J. Biol. Chem. 271 (35): 21514–21. doi:10.1074/jbc.271.35.21514. PMID 8702936. 
  2. ^ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480. 
  3. ^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1997). "Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13". Genomics 40 (1): 211–3. doi:10.1006/geno.1996.4552. PMID 9070951. 
  4. ^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168. 

Further reading[edit]