CCL19

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Chemokine (C-C motif) ligand 19
Identifiers
Symbols CCL19 ; CKb11; ELC; MIP-3b; MIP3B; SCYA19
External IDs OMIM602227 MGI1346316 HomoloGene4569 GeneCards: CCL19 Gene
RNA expression pattern
PBB GE CCL19 210072 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6363 24047
Ensembl ENSG00000172724 ENSMUSG00000071005
UniProt Q99731 O70460
RefSeq (mRNA) NM_006274 NM_011888
RefSeq (protein) NP_006265 NP_036018
Location (UCSC) Chr 9:
34.69 – 34.69 Mb
Chr 4:
42.75 – 42.76 Mb
PubMed search [1] [2]

C-C motif chemokine 19 is a protein that in humans is encoded by the CCL19 gene.[1][2]

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.[2]

Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.[3] The gene for CCL19 is located on human chromosome 9.[4] This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7.[3] It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells,[5][6] CCR7+ central-memory T-Cells.[7]

References[edit]

  1. ^ Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J Biol Chem 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236. 
  2. ^ a b "Entrez Gene: CCL19 chemokine (C-C motif) ligand 19". 
  3. ^ a b Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236. 
  4. ^ Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. PMID 9013939. 
  5. ^ Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes". Cell 103 (5): 757–68. doi:10.1016/S0092-8674(00)00179-3. PMID 11114332. 
  6. ^ Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position". Nature 416 (6876): 94–9. doi:10.1038/416094a. PMID 11882900. 
  7. ^ Bromley SK, Thomas SY, Luster AD (2005). "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics". Nat. Immunol. 6 (9): 895–901. doi:10.1038/ni1240. PMID 16116469. 

Further reading[edit]