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For the aerodrome using the TC LID, CCL3, see Christina Lake Aerodrome.
Chemokine (C-C motif) ligand 3
Protein CCL3 PDB 1b50.png
PDB rendering based on 1b50.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CCL3 ; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
External IDs OMIM182283 HomoloGene88430 GeneCards: CCL3 Gene
RNA expression pattern
PBB GE CCL3 205114 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6348 20302
Ensembl ENSG00000006075 ENSMUSG00000000982
UniProt P10147 P10855
RefSeq (mRNA) NM_002983 NM_011337
RefSeq (protein) NP_002974 NP_035467
Location (UCSC) Chr 17:
34.42 – 34.42 Mb
Chr 11:
83.65 – 83.65 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 3 (CCL3) is a protein that in humans is encoded by the CCL3 gene.

CCL3, also known as macrophage inflammatory protein 1α (MIP1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.[1]


CCL3 has been shown to interact with CCL4.[2]

See also[edit]


  1. ^ "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3". 
  2. ^ Guan, E; Wang J; Norcross M A (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". J. Biol. Chem. (United States) 276 (15): 12404–9. doi:10.1074/jbc.M006327200. ISSN 0021-9258. PMID 11278300. 

Further reading[edit]

  • Menten P, Wuyts A, Van Damme J (2003). "Macrophage inflammatory protein-1.". Cytokine Growth Factor Rev. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480. 
  • Muthumani K, Desai BM, Hwang DS et al. (2004). "HIV-1 Vpr and anti-inflammatory activity.". DNA Cell Biol. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726. 
  • Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation.". Cell Res. 15 (3): 143–9. doi:10.1038/ PMID 15780175. 
  • Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses.". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944. 
  • Li L, Li HS, Pauza CD et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.". Cell Res. 15 (11–12): 923–34. doi:10.1038/ PMID 16354571.