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Chemokine (C-C motif) ligand 3

PDB rendering based on 1b50.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CCL3 ; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
External IDs OMIM182283 HomoloGene88430 GeneCards: CCL3 Gene
RNA expression pattern
PBB GE CCL3 205114 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6348 n/a
Ensembl ENSG00000006075 n/a
UniProt P10147 n/a
RefSeq (mRNA) NM_002983 n/a
RefSeq (protein) NP_002974 n/a
Location (UCSC) Chr 17:
34.42 – 34.42 Mb
PubMed search [1] n/a

Chemokine (C-C motif) ligand 3 (CCL3) is a protein that in humans is encoded by the CCL3 gene.

CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM][1]


CCL3 has been shown to interact with CCL4.[2]

See also[edit]


  1. ^ "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3". 
  2. ^ Guan, E; Wang J, Norcross M A (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". J. Biol. Chem. (United States) 276 (15): 12404–9. doi:10.1074/jbc.M006327200. ISSN 0021-9258. PMID 11278300. 

Further reading[edit]