CCL4

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For carbon tetrachloride, with formula CCl4, see Carbon tetrachloride.
Chemokine (C-C motif) ligand 4
Protein CCL4 PDB 1hum.png
PDB rendering based on 1hum.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CCL4 ; ACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4
External IDs OMIM182284 MGI98261 HomoloGene48153 GeneCards: CCL4 Gene
RNA expression pattern
PBB GE CCL4 204103 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6351 20303
Ensembl ENSG00000129277 ENSMUSG00000018930
UniProt P13236 P14097
RefSeq (mRNA) NM_002984 NM_013652
RefSeq (protein) NP_002975 NP_038680
Location (UCSC) Chr 17:
34.43 – 34.43 Mb
Chr 11:
83.66 – 83.66 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene.[1]

Function[edit]

CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.[2]

CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.[3]

Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.[4]

Interactions[edit]

CCL4 has been shown to interact with CCL3.[5]

See also[edit]

References[edit]

  1. ^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563. 
  2. ^ Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nat. Immunol. 2 (12): 1126–32. doi:10.1038/ni735. PMID 11702067. 
  3. ^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science 270 (5243): 1811–5. doi:10.1126/science.270.5243.1811. PMID 8525373. 
  4. ^ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the β-chemokine macrophage inflammatory protein-1β". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9283–8. doi:10.1073/pnas.161298998. PMC 55412. PMID 11470920. 
  5. ^ Guan, E; Wang J; Norcross M A (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". J. Biol. Chem. (United States) 276 (15): 12404–9. doi:10.1074/jbc.M006327200. ISSN 0021-9258. PMID 11278300. 


Further reading[edit]