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Chemokine (C-C motif) ligand 7
Protein CCL7 PDB 1bo0.png
PDB rendering based on 1bo0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CCL7 ; FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7
External IDs OMIM158106 MGI99512 HomoloGene4568 GeneCards: CCL7 Gene
RNA expression pattern
PBB GE CCL7 208075 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6354 20306
Ensembl ENSG00000108688 ENSMUSG00000035373
UniProt P80098 Q03366
RefSeq (mRNA) NM_006273 NM_013654
RefSeq (protein) NP_006264 NP_038682
Location (UCSC) Chr 17:
32.6 – 32.6 Mb
Chr 11:
82.05 – 82.05 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages.[1] This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines[2] and is most closely related to CCL2 (previously called MCP1).


CCL7 has been shown to interact with MMP2.[3]


  1. ^ Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines". Biochem. Biophys. Res. Commun. 191 (2): 535–42. doi:10.1006/bbrc.1993.1251. PMID 8461011. 
  2. ^ Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328. 
  3. ^ McQuibban, G A; Gong J H; Tam E M; McCulloch C A; Clark-Lewis I; Overall C M (August 2000). "Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3". Science (UNITED STATES) 289 (5482): 1202–6. doi:10.1126/science.289.5482.1202. ISSN 0036-8075. PMID 10947989. 

Further reading[edit]