CCL9

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Chemokine (C-C motif) ligand 9
Identifiers
Symbols Ccl9 ; CCF18; MRP-2; Scya10; Scya9
External IDs MGI104533 HomoloGene86734 GeneCards: Ccl9 Gene
Orthologs
Species Human Mouse
Entrez 20308 20308
Ensembl ENSMUSG00000019122 ENSMUSG00000019122
UniProt P51670 P51670
RefSeq (mRNA) NM_011338 NM_011338
RefSeq (protein) NP_035468 NP_035468
Location (UCSC) Chr 11:
83.57 – 83.58 Mb
Chr 11:
83.57 – 83.58 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family. It is also called macrophage inflammatory protein-1 gamma (MIP-1γ), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18, that has been described in rodents. CCL9 has also been previously designated CCL10, although this name is no longer in use. It is secreted by follicle-associated epithelium (FAE) such as that found around Peyer's patches, and attracts dendritic cells that possess the cell surface molecule CD11b and the chemokine receptor CCR1.[1] CCL9 can activate osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in bone resorption.[2] CCL9 is constitutively expressed in macrophages and myeloid cells.[3][4] The gene for CCL9 is located on chromosome 11 in mice.[4]

References[edit]

  1. ^ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A (2003). "CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells". J Immunol 171 (6): 2797–803. PMID 12960300. 
  2. ^ Lean J, Murphy C, Fuller K, Chambers T (2002). "CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts". J Cell Biochem 87 (4): 386–93. doi:10.1002/jcb.10319. PMID 12397598. 
  3. ^ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B (1995). "A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors". J Immunol 155 (5): 2661–7. PMID 7650394. 
  4. ^ a b Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A (1995). "Molecular cloning and functional characterization of a novel member of the C-C chemokine family". J Immunol 155 (11): 5352–8. PMID 7594550.