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CCNF may also mean Canonical conjunctive normal form in Boolean algebra.
Cyclin F
Symbols CCNF ; FBX1; FBXO1
External IDs OMIM600227 MGI102551 HomoloGene1335 GeneCards: CCNF Gene
RNA expression pattern
PBB GE CCNF 204826 at tn.png
PBB GE CCNF 204827 s at tn.png
More reference expression data
Species Human Mouse
Entrez 899 12449
Ensembl ENSG00000162063 ENSMUSG00000072082
UniProt P41002 P51944
RefSeq (mRNA) NM_001761 NM_007634
RefSeq (protein) NP_001752 NP_031660
Location (UCSC) Chr 16:
2.48 – 2.51 Mb
Chr 17:
24.22 – 24.25 Mb
PubMed search [1] [2]

G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene.[1][2]

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.[2]


  1. ^ Kraus B, Pohlschmidt M, Leung AL, Germino GG, Snarey A, Schneider MC, Reeders ST, Frischauf AM (Apr 1995). "A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1)". Genomics 24 (1): 27–33. doi:10.1006/geno.1994.1578. PMID 7896286. 
  2. ^ a b "Entrez Gene: CCNF cyclin F". 

Further reading[edit]