CCNG1

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Cyclin G1
Identifiers
Symbols CCNG1 ; CCNG
External IDs OMIM601578 MGI102890 HomoloGene2995 GeneCards: CCNG1 Gene
RNA expression pattern
PBB GE CCNG1 208796 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 900 12450
Ensembl ENSG00000113328 ENSMUSG00000020326
UniProt P51959 P51945
RefSeq (mRNA) NM_004060 NM_009831
RefSeq (protein) NP_004051 NP_033961
Location (UCSC) Chr 5:
162.86 – 162.87 Mb
Chr 11:
40.75 – 40.76 Mb
PubMed search [1] [2]

Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.[1][2][3]

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.[3]

Interactions[edit]

CCNG1 has been shown to interact with P16,[4] Mdm2,[4] PPP2R4[5] and P53.[4]

References[edit]

  1. ^ Endo Y, Fujita T, Tamura K, Tsuruga H, Nojima H (Mar 1997). "Structure and chromosomal assignment of the human cyclin G gene". Genomics 38 (1): 92–5. doi:10.1006/geno.1996.0598. PMID 8954786. 
  2. ^ Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene 13 (5): 1103–9. PMID 8806701. 
  3. ^ a b "Entrez Gene: CCNG1 cyclin G1". 
  4. ^ a b c Zhao, Lili; Samuels Tina; Winckler Sarah; Korgaonkar Chandrashekhar; Tompkins Van; Horne Mary C; Quelle Dawn E (Jan 2003). "Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways". Mol. Cancer Res. (United States) 1 (3): 195–206. ISSN 1541-7786. PMID 12556559. 
  5. ^ Okamoto, K; Kamibayashi C; Serrano M; Prives C; Mumby M C; Beach D (Nov 1996). "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A". Mol. Cell. Biol. (UNITED STATES) 16 (11): 6593–602. ISSN 0270-7306. PMC 231661. PMID 8887688. 

Further reading[edit]