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Cyclin G2
Symbol CCNG2
External IDs OMIM603203 MGI1095734 HomoloGene3208 GeneCards: CCNG2 Gene
RNA expression pattern
PBB GE CCNG2 202769 at tn.png
PBB GE CCNG2 202770 s at tn.png
PBB GE CCNG2 211559 s at tn.png
More reference expression data
Species Human Mouse
Entrez 901 12452
Ensembl ENSG00000138764 ENSMUSG00000029385
UniProt Q16589 O08918
RefSeq (mRNA) NM_004354 NM_007635
RefSeq (protein) NP_004345 NP_031661
Location (UCSC) Chr 4:
78.08 – 78.35 Mb
Chr 5:
93.27 – 93.28 Mb
PubMed search [1] [2]

Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene.[1][2]


The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.[2]


CCNG2 has been shown to interact with PPP2CA.[3]


  1. ^ Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene 13 (5): 1103–9. PMID 8806701. 
  2. ^ a b "Entrez Gene: CCNG2 cyclin G2". 
  3. ^ Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L et al. (Jul 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189. 

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