CCR10

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Chemokine (C-C motif) receptor 10
Identifiers
Symbols CCR10 ; GPR2
External IDs OMIM600240 MGI1096320 HomoloGene7271 IUPHAR: CCR10 GeneCards: CCR10 Gene
RNA expression pattern
PBB GE CCR10 220565 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2826 12777
Ensembl ENSG00000184451 ENSMUSG00000044052
UniProt P46092 Q9JL21
RefSeq (mRNA) NM_016602 NM_007721
RefSeq (protein) NP_057686 NP_031747
Location (UCSC) Chr 17:
40.83 – 40.84 Mb
Chr 11:
101.17 – 101.18 Mb
PubMed search [1] [2]

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.[1][2]

Function[edit]

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.[2]

CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28.[3] This receptor is normally expressed by melanocytes,[4] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin,[5] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.[6]

References[edit]

  1. ^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889. 
  2. ^ a b "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10". 
  3. ^ Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. Cancer 4 (7): 540–50. doi:10.1038/nrc1388. PMID 15229479. 
  4. ^ Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. PMID 10725697. 
  5. ^ Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST (November 2003). "Immune evasion by murine melanoma mediated through CC chemokine receptor-10". J. Exp. Med. 198 (9): 1337–47. doi:10.1084/jem.20030593. PMC 2194242. PMID 14581607. 
  6. ^ Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. 

Further reading[edit]

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Bonini JA, Martin SK, Dralyuk F et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936. 
  • Gosling J, Dairaghi DJ, Wang Y et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. PMID 10706668. 
  • Jarmin DI, Rits M, Bota D et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine". J. Immunol. 164 (7): 3460–4. PMID 10725696. 
  • Homey B, Wang W, Soto H et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. PMID 10725697. 
  • Wang W, Soto H, Oldham ER et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587. 
  • Pan J, Kunkel EJ, Gosslar U et al. (2000). "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues". J. Immunol. 165 (6): 2943–9. PMID 10975800. 
  • Patel L, Charlton SJ, Chambers JK, Macphee CH (2001). "Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations". Cytokine 14 (1): 27–36. doi:10.1006/cyto.2000.0851. PMID 11298490. 
  • Homey B, Alenius H, Müller A et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Lehner B, Semple JI, Brown SE et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Notohamiprodjo M, Segerer S, Huss R et al. (2005). "CCR10 is expressed in cutaneous T-cell lymphoma". Int. J. Cancer 115 (4): 641–7. doi:10.1002/ijc.20922. PMID 15700309. 
  • Rodrigues-Lisoni FC, Mehet DK, Mehemet DK et al. (2006). "In vitro and in vivo studies on CCR10 regulation by Annexin A1". FEBS Lett. 580 (5): 1431–8. doi:10.1016/j.febslet.2006.01.072. PMID 16460738. 
  • Fujita Y, Abe R, Sasaki M et al. (2006). "Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides". Clin. Cancer Res. 12 (9): 2670–5. doi:10.1158/1078-0432.CCR-05-1513. PMID 16675558. 
  • Eksteen B, Miles A, Curbishley SM et al. (2006). "Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10". J. Immunol. 177 (1): 593–603. PMID 16785557. 
  • Harasawa H, Yamada Y, Hieshima K et al. (2007). "Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma". Leuk. Lymphoma 47 (10): 2163–73. doi:10.1080/10428190600775599. PMID 17071491. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.