CCR10

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Chemokine (C-C motif) receptor 10
Identifiers
Symbols CCR10 ; GPR2
External IDs OMIM600240 MGI1096320 HomoloGene7271 IUPHAR: CCR10 GeneCards: CCR10 Gene
RNA expression pattern
PBB GE CCR10 220565 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2826 12777
Ensembl ENSG00000184451 ENSMUSG00000044052
UniProt P46092 Q9JL21
RefSeq (mRNA) NM_016602 NM_007721
RefSeq (protein) NP_057686 NP_031747
Location (UCSC) Chr 17:
40.83 – 40.84 Mb
Chr 11:
101.17 – 101.18 Mb
PubMed search [1] [2]

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.[1][2]

Function[edit]

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.[2]

CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28.[3] This receptor is normally expressed by melanocytes,[4] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin,[5] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.[6]

References[edit]

  1. ^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889. 
  2. ^ a b "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10". 
  3. ^ Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. Cancer 4 (7): 540–50. doi:10.1038/nrc1388. PMID 15229479. 
  4. ^ Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697. 
  5. ^ Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST (November 2003). "Immune evasion by murine melanoma mediated through CC chemokine receptor-10". J. Exp. Med. 198 (9): 1337–47. doi:10.1084/jem.20030593. PMC 2194242. PMID 14581607. 
  6. ^ Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.