CCR3 (gene)

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Chemokine (C-C motif) receptor 3
Identifiers
Symbols CCR3 ; CC-CKR-3; CD193; CKR3; CMKBR3
External IDs OMIM601268 MGI104616 HomoloGene20436 IUPHAR: CCR3 ChEMBL: 3473 GeneCards: CCR3 Gene
RNA expression pattern
PBB GE CCR3 208304 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1232 12771
Ensembl ENSG00000183625 ENSMUSG00000035448
UniProt P51677 P51678
RefSeq (mRNA) NM_001164680 NM_009914
RefSeq (protein) NP_001158152 NP_034044
Location (UCSC) Chr 3:
46.21 – 46.31 Mb
Chr 9:
124.02 – 124.03 Mb
PubMed search [1] [2]

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.[1]

CCR3 has also recently been designated CD193 (cluster of differentiation 193).

Function[edit]

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils,[2] and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.[1]

See also[edit]

Interactions[edit]

CCR3 (gene) has been shown to interact with CCL5.[3][4][5]

References[edit]

  1. ^ a b "Entrez Gene: CCR3 chemokine (C-C motif) receptor 3". 
  2. ^ •Murphy KM, P Travers, M Walport (Eds.) (2010) Janeway's Immunobiology. 8th Edition. New York:Taylor & Francis, Inc.
  3. ^ Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR. "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils". J. Exp. Med. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064. 
  4. ^ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". J. Exp. Med. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344. 
  5. ^ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::aid-immu2170>3.0.co;2-d. PMID 11449371. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.