CCR8 (gene)

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Chemokine (C-C motif) receptor 8
Identifiers
Symbols CCR8 ; CC-CKR-8; CCR-8; CDw198; CKRL1; CMKBR8; CMKBRL2; CY6; GPRCY6; TER1
External IDs OMIM601834 MGI1201402 HomoloGene21080 IUPHAR: CCR8 ChEMBL: 4596 GeneCards: CCR8 Gene
RNA expression pattern
PBB GE CCR8 208059 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1237 12776
Ensembl ENSG00000179934 ENSMUSG00000042262
UniProt P51685 P56484
RefSeq (mRNA) NM_005201 NM_007720
RefSeq (protein) NP_005192 NP_031746
Location (UCSC) Chr 3:
39.37 – 39.38 Mb
Chr 9:
120.09 – 120.09 Mb
PubMed search [1] [2]

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene.[1] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

Function[edit]

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1.[2]

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.[1]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: CCR8 chemokine (C-C motif) receptor 8". 
  2. ^ Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP (October 1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332. 

External links[edit]

  • "Chemokine Receptors: CCR8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.