CCRL1

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Atypical chemokine receptor 4
Identifiers
Symbols ACKR4 ; CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11; CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1
External IDs OMIM606065 MGI2181676 HomoloGene49474 IUPHAR: ChEMBL: 2917 GeneCards: ACKR4 Gene
Orthologs
Species Human Mouse
Entrez 51554 252837
Ensembl ENSG00000129048 ENSMUSG00000079355
UniProt Q9NPB9 Q924I3
RefSeq (mRNA) NM_016557 NM_145700
RefSeq (protein) NP_057641 NP_663746
Location (UCSC) Chr 3:
132.32 – 132.34 Mb
Chr 9:
104.1 – 104.13 Mb
PubMed search [1] [2]

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.[1][2]

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.[2]

References[edit]

  1. ^ Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V (May 2000). "Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart". Gene 246 (1–2): 229–38. doi:10.1016/S0378-1119(00)00076-7. PMID 10767544. 
  2. ^ a b "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.