This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.
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Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21.". Genomics41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID9143512.
Muzny DM; Scherer SE; Kaul R et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature440 (7088): 1194–8. doi:10.1038/nature04728. PMID16641997.Cite uses deprecated parameter |author-separator= (help)