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Chemokine (C-C motif) receptor-like 2
External IDs OMIM608379 MGI1920904 HomoloGene2948 IUPHAR: 78 GeneCards: CCRL2 Gene
Species Human Mouse
Entrez 9034 54199
Ensembl ENSG00000121797 ENSMUSG00000043953
UniProt O00421 O35457
RefSeq (mRNA) NM_001130910 NM_017466
RefSeq (protein) NP_001124382 NP_059494
Location (UCSC) Chr 3:
46.45 – 46.45 Mb
Chr 9:
111.05 – 111.06 Mb
PubMed search [1] [2]

C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.[1][2] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.[3]


This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.[2]


  1. ^ Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y (Mar 1998). "Cloning and characterization of a novel human chemokine receptor". Biochem Biophys Res Commun 243 (1): 264–8. doi:10.1006/bbrc.1997.7981. PMID 9473515. 
  2. ^ a b "Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2". 
  3. ^ Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC (September 2008). "Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis". J. Exp. Med. 205 (10): 2207–20. doi:10.1084/jem.20080300. PMC 2556791. PMID 18794339. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.