CCS (gene)

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Copper chaperone for superoxide dismutase
Protein CCS PDB 1do5.png
PDB rendering based on 1do5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CCS ; MGC138260
External IDs OMIM603864 MGI1333783 HomoloGene3762 GeneCards: CCS Gene
RNA expression pattern
PBB GE CCS 203522 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9973 12460
Ensembl ENSG00000173992 ENSMUSG00000034108
UniProt O14618 Q9WU84
RefSeq (mRNA) NM_005125 NM_016892
RefSeq (protein) NP_005116 NP_058588
Location (UCSC) Chr 11:
66.36 – 66.37 Mb
Chr 19:
4.83 – 4.84 Mb
PubMed search [1] [2]

Copper chaperone for superoxide dismutase is a metalloprotein that in humans is encoded by the CCS gene.[1][2]

Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.[2]

Interactions[edit]

CCS (gene) has been shown to interact with SOD1[3] and APBA1.[4]

References[edit]

  1. ^ Culotta VC, Klomp LW, Strain J, Casareno RL, Krems B, Gitlin JD (Oct 1997). "The copper chaperone for superoxide dismutase". J Biol Chem 272 (38): 23469–72. doi:10.1074/jbc.272.38.23469. PMID 9295278. 
  2. ^ a b "Entrez Gene: CCS copper chaperone for superoxide dismutase". 
  3. ^ Casareno, R L; Waggoner D; Gitlin J D (Sep 1998). "The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase". J. Biol. Chem. (UNITED STATES) 273 (37): 23625–8. doi:10.1074/jbc.273.37.23625. ISSN 0021-9258. PMID 9726962. 
  4. ^ McLoughlin, D M; Standen C L; Lau K F; Ackerley S; Bartnikas T P; Gitlin J D; Miller C C (Mar 2001). "The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity". J. Biol. Chem. (United States) 276 (12): 9303–7. doi:10.1074/jbc.M010023200. ISSN 0021-9258. PMID 11115513. 

Further reading[edit]