CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.
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Sincock PM, Mayrhofer G, Ashman LK (1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". J. Histochem. Cytochem.45 (4): 515–25. doi:10.1177/002215549704500404. PMID9111230.
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Fitter S, Seldin MF, Ashman LK (1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms". Biochim. Biophys. Acta1398 (1): 75–85. doi:10.1016/S0167-4781(98)00034-7. PMID9602068.
Sincock PM, Fitter S, Parton RG et al. (1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function". J. Cell. Sci. 112 ( Pt 6): 833–44. PMID10036233.
Testa JE, Brooks PC, Lin JM, Quigley JP (1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis". Cancer Res.59 (15): 3812–20. PMID10447000.
Whittock NV, McLean WH (2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene". Biochem. Biophys. Res. Commun.281 (2): 425–30. doi:10.1006/bbrc.2001.4384. PMID11181065.
Charrin S, Le Naour F, Oualid M et al. (2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem.276 (17): 14329–37. doi:10.1074/jbc.M011297200. PMID11278880.
Kohno M, Hasegawa H, Miyake M et al. (2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". Int. J. Cancer97 (3): 336–43. doi:10.1002/ijc.1605. PMID11774285.