CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.
Hasegawa H, Utsunomiya Y, Kishimoto K et al. (1996). "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily". J. Virol.70 (5): 3258–63. PMC190191. PMID8627808.
Hasegawa H, Kishimoto K, Yanagisawa K et al. (1997). "Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization". Genomics40 (1): 193–6. doi:10.1006/geno.1996.4563. PMID9070943.
Sincock PM, Mayrhofer G, Ashman LK (1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". J. Histochem. Cytochem.45 (4): 515–25. doi:10.1177/002215549704500404. PMID9111230.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Fitter S, Seldin MF, Ashman LK (1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms". Biochim. Biophys. Acta1398 (1): 75–85. doi:10.1016/S0167-4781(98)00034-7. PMID9602068.
Sincock PM, Fitter S, Parton RG et al. (1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function". J. Cell. Sci. 112 ( Pt 6): 833–44. PMID10036233.
Serru V, Le Naour F, Billard M et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J.340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC1220227. PMID10229664.
Testa JE, Brooks PC, Lin JM, Quigley JP (1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis". Cancer Res.59 (15): 3812–20. PMID10447000.
Sterk LM, Geuijen CA, Oomen LC et al. (2000). "The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes". J. Cell Biol.149 (4): 969–82. doi:10.1083/jcb.149.4.969. PMC2174566. PMID10811835.
Whittock NV, McLean WH (2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene". Biochem. Biophys. Res. Commun.281 (2): 425–30. doi:10.1006/bbrc.2001.4384. PMID11181065.
Charrin S, Le Naour F, Oualid M et al. (2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem.276 (17): 14329–37. doi:10.1074/jbc.M011297200. PMID11278880.
Suzuki Y, Tsunoda T, Sese J et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res.11 (5): 677–84. doi:10.1101/gr.164001. PMC311086. PMID11337467.
Kohno M, Hasegawa H, Miyake M et al. (2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". Int. J. Cancer97 (3): 336–43. doi:10.1002/ijc.1605. PMID11774285.