CD160

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CD160 molecule
Identifiers
Symbols CD160 ; BY55; NK1; NK28
External IDs OMIM604463 MGI1860383 HomoloGene5122 GeneCards: CD160 Gene
RNA expression pattern
PBB GE CD160 207840 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11126 54215
Ensembl ENSG00000117281 ENSMUSG00000038304
UniProt O95971 O88875
RefSeq (mRNA) NM_007053 NM_001163496
RefSeq (protein) NP_008984 NP_001156968
Location (UCSC) Chr 1:
145.7 – 145.72 Mb
Chr 3:
96.8 – 96.83 Mb
PubMed search [1] [2]

CD160 antigen is a protein that in humans is encoded by the CD160 gene.[1][2][3]

CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.[3]

Clinical significance[edit]

CD160 as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.


Related gene problems[edit]

See also[edit]

References[edit]

  1. ^ Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ (Oct 1998). "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes". J Immunol 161 (6): 2780–90. PMID 9743336. 
  2. ^ Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A (Apr 1999). "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells". J Immunol 162 (3): 1223–6. PMID 9973372. 
  3. ^ a b "Entrez Gene: CD160 CD160 molecule". 
  4. ^ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129. 

Further reading[edit]

External links[edit]

Skin Research Center lab Hopital St Louis, Paris (France) Dir. Dr. A. Bensussan