CD180

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CD180 molecule
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CD180 ; LY64; Ly78; RP105
External IDs OMIM602226 MGI1194924 HomoloGene4077 GeneCards: CD180 Gene
RNA expression pattern
PBB GE CD180 206206 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4064 17079
Ensembl ENSG00000134061 ENSMUSG00000021624
UniProt Q99467 Q62192
RefSeq (mRNA) NM_005582 NM_008533
RefSeq (protein) NP_005573 NP_032559
Location (UCSC) Chr 5:
66.48 – 66.49 Mb
Chr 13:
102.69 – 102.74 Mb
PubMed search [1] [2]

CD180 antigen is a protein that in humans is encoded by the CD180 gene.[1][2][3]

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.[3]

References[edit]

  1. ^ Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood 92 (8): 2815–22. PMID 9763566. 
  2. ^ Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID 8975706. 
  3. ^ a b "Entrez Gene: CD180 CD180 molecule". 

Further reading[edit]