CD1D

CD1d molecule
PDB rendering based on 1zt4.
Available structures PDB 1ZT4, 2PO6, 3HUJ
Identifiers
Symbols	CD1D; CD1A; MGC34622; R3
External IDs	OMIM: 188410 MGI: 107674 HomoloGene: 1337 GeneCards: CD1D Gene
Gene Ontology Molecular function • receptor activity • beta-2-microglobulin binding • exogenous lipid antigen binding • histone binding Cellular component • lysosomal membrane • endosome • plasma membrane • integral to plasma membrane • endosome membrane Biological process • detection of bacterium • antigen processing and presentation • interspecies interaction between organisms • T cell selection • positive regulation of innate immune response • antigen processing and presentation, endogenous lipid antigen via MHC class Ib Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	912	12479
Ensembl	ENSG00000158473	ENSMUSG00000028076
UniProt	P15813	Q91XK9
RefSeq (mRNA)	NM_001766.3	NM_007639.3
RefSeq (protein)	NP_001757.1	NP_031665.2
Location (UCSC)	Chr 1: 158.15 – 158.15 Mb	Chr 3: 86.8 – 86.8 Mb
PubMed search	[1]	[2]

CD1d is a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules.

CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.

Nomenclature

• CD1d is also known as R3G1

Further reading

• Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules.". Curr. Opin. Immunol. 8 (1): 82–8. doi:10.1016/S0952-7915(96)80109-9. PMID 8729450. 
• Joyce S (2001). "CD1d and natural T cells: how their properties jump-start the immune system.". Cell. Mol. Life Sci. 58 (3): 442–69. doi:10.1007/PL00000869. PMID 11315191. 
• Sköld M, Behar SM (2003). "Role of CD1d-Restricted NKT Cells in Microbial Immunity". Infect. Immun. 71 (10): 5447–55. doi:10.1128/IAI.71.10.5447-5455.2003. PMC 201095. PMID 14500461. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=201095. 
• Brigl M, Brenner MB (2004). "CD1: antigen presentation and T cell function". Annu. Rev. Immunol. 22: 817–90. doi:10.1146/annurev.immunol.22.012703.104608. PMID 15032598. 
• Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711. 
• Brutkiewicz RR (2006). "CD1d ligands: the good, the bad, and the ugly". J. Immunol. 177 (2): 769–75. PMID 16818729. 
• Blumberg RS, Terhorst C, Bleicher P, et al. (1991). "Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells". J. Immunol. 147 (8): 2518–24. PMID 1717564. 
• Balk SP, Bleicher PA, Terhorst C (1989). "Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 252–6. doi:10.1073/pnas.86.1.252. PMC 286442. PMID 2463622. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=286442. 
• Calabi F, Jarvis JM, Martin L, Milstein C (1989). "Two classes of CD1 genes". Eur. J. Immunol. 19 (2): 285–92. doi:10.1002/eji.1830190211. PMID 2467814. 
• Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes". EMBO J. 8 (12): 3727–32. PMC 402056. PMID 2583117. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=402056. 
• Martin LH, Calabi F, Milstein C (1987). "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154–8. doi:10.1073/pnas.83.23.9154. PMC 387093. PMID 3097645. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387093. 
• Balk SP, Burke S, Polischuk JE, et al. (1994). "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium". Science 265 (5169): 259–62. doi:10.1126/science.7517575. PMID 7517575. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Kawano T, Cui J, Koezuka Y, et al. (1997). "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides". Science 278 (5343): 1626–9. doi:10.1126/science.278.5343.1626. PMID 9374463. 
• Katabami S, Matsuura A, Chen HZ, et al. (1998). "Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes". Immunogenetics 48 (1): 22–31. doi:10.1007/s002510050396. PMID 9601940. 
• Somnay-Wadgaonkar K, Nusrat A, Kim HS, et al. (1999). "Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form". Int. Immunol. 11 (3): 383–92. doi:10.1093/intimm/11.3.383. PMID 10221650. 
• Campbell NA, Kim HS, Blumberg RS, Mayer L (1999). "The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells". J. Biol. Chem. 274 (37): 26259–65. doi:10.1074/jbc.274.37.26259. PMID 10473580. 
• Han M, Hannick LI, DiBrino M, Robinson MA (2000). "Polymorphism of human CD1 genes". Tissue Antigens 54 (2): 122–7. doi:10.1034/j.1399-0039.1999.540202.x. PMID 10488738. 

External links

• MeSH CD1d+antigen