CD200R1
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| CD200 receptor 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CD200R1; CD200R; HCRTR2; MOX2R; OX2R | ||||||||||||
| External IDs | OMIM: 607546 MGI: 1889024 HomoloGene: 10957 GeneCards: CD200R1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 131450 | 57781 | |||||||||||
| Ensembl | ENSG00000163606 | ENSMUSG00000022667 | |||||||||||
| UniProt | Q8TD46 | Q9ES57 | |||||||||||
| RefSeq (mRNA) | NM_138806.3 | NM_021325.3 | |||||||||||
| RefSeq (protein) | NP_620161.1 | NP_067300.1 | |||||||||||
| Location (UCSC) | Chr 3: 112.64 – 112.69 Mb |
Chr 16: 44.77 – 44.8 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.[1][2][3]
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.[3]
[edit] References
- ^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (Sep 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
- ^ Dick AD, Broderick C, Forrester JV, Wright GJ (Jan 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Invest Ophthalmol Vis Sci 42 (1): 170–6. PMID 11133863.
- ^ a b "Entrez Gene: CD200R1 CD200 receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=131450.
[edit] Further reading
- Matsue H (2006). "CD 200-mediated regulation of skin immunity.". J. Invest. Dermatol. 125 (6): x-xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.
- Shiratori I, Yamaguchi M, Suzukawa M, et al. (2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200.". J. Immunol. 175 (7): 4441–9. PMID 16177086.
- Cherwinski HM, Murphy CA, Joyce BL, et al. (2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function.". J. Immunol. 174 (3): 1348–56. PMID 15661892.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551.
- Foster-Cuevas M, Wright GJ, Puklavec MJ, et al. (2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.". J. Virol. 78 (14): 7667–76. doi:10.1128/JVI.78.14.7667-7676.2004. PMC 434103. PMID 15220441. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=434103.
- Karteris E, Chen J, Randeva HS (2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.". J. Clin. Endocrinol. Metab. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Wright GJ, Cherwinski H, Foster-Cuevas M, et al. (2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.". J. Immunol. 171 (6): 3034–46. PMID 12960329.
- Vieites JM, de la Torre R, Ortega MA, et al. (2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13.". Gene 311: 99–104. doi:10.1016/S0378-1119(03)00562-6. PMID 12853143.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
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