Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell-cell adhesion processes but also in host defence. This family comprise two other members, CD93 and Thrombomodulin which are better characterized. Even though the function of endosialin remains elusive, its expression has been associated with angiogenesis in the embryo, uterus and in tumor development and growth.
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