CD27

CD27 molecule
Identifiers
Symbols	CD27; MGC20393; S152; T14; TNFRSF7; Tp55
External IDs	OMIM: 186711 MGI: 88326 HomoloGene: 74386 GeneCards: CD27 Gene
Gene Ontology
Molecular function	• transmembrane receptor activity; • protein binding; • caspase inhibitor activity;
Cellular component	• extracellular region; • membrane fraction; • integral to plasma membrane; • cell surface; • membrane;
Biological process	• apoptosis; • anti-apoptosis; • anti-apoptosis; • induction of apoptosis; • induction of apoptosis; • cell surface receptor linked signaling pathway; • release of cytoplasmic sequestered NF-kappaB; • immunoglobulin mediated immune response; • negative regulation of caspase activity; • response to ethanol; • positive regulation of B cell differentiation; • positive regulation of JNK cascade;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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CD27 is a tumor necrosis factor receptor.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.^[1]

[edit] Interactions

CD27 has been shown to interact with SIVA1,^[2] TRAF2^[3]^[4] and TRAF3.^[3]^[4]

[edit] References

^ "Entrez Gene: CD27 CD27 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=939.
^ Prasad, K V; Ao Z, Yoon Y, Wu M X, Rizk M, Jacquot S, Schlossman S F (Jun. 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. ISSN 0027-8424. PMC 21052. PMID 9177220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21052.
^ ^a ^b Yamamoto, H; Kishimoto T, Minamoto S (Nov. 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753–9. ISSN 0022-1767. PMID 9794406.
^ ^a ^b Akiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May. 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. ISSN 0021-9258. PMID 9582383.

[edit] Further reading

Lens SM, de Jong R, Hintzen RQ, et al. (1996). "CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth.". Leuk. Lymphoma 18 (1–2): 51–9. doi:10.3109/10428199509064922. PMID 8580829.
Agematsu K (2000). "Memory B cells and CD27". Histol. Histopathol. 15 (2): 573–6. PMID 10809378.
van Baarle D, Kostense S, van Oers MH, et al. (2003). "Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue". Trends Immunol. 23 (12): 586–91. doi:10.1016/S1471-4906(02)02326-8. PMID 12464570.
Dörner T, Lipsky PE (2005). "Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus". Lupus 13 (5): 283–9. doi:10.1191/0961203304lu1014oa. PMID 15230280.

[edit] External links

MeSH CD27+Antigens

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[0] "Entrez Gene: CD27 CD27 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=939.

[pmid9177220-1] Prasad, K V; Ao Z, Yoon Y, Wu M X, Rizk M, Jacquot S, Schlossman S F (Jun. 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. ISSN 0027-8424. PMC 21052. PMID 9177220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21052.

[pmid9794406-2] Yamamoto, H; Kishimoto T, Minamoto S (Nov. 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753–9. ISSN 0022-1767. PMID 9794406.

[pmid9582383-3] Akiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May. 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. ISSN 0021-9258. PMID 9582383.

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CD27

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