The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
^ abYamamoto, H; Kishimoto T, Minamoto S (Nov. 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753–9. ISSN0022-1767. PMID9794406.
^ abAkiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May. 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. ISSN0021-9258. PMID9582383.
Lens SM, de Jong R, Hintzen RQ, et al. (1996). "CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth.". Leuk. Lymphoma18 (1–2): 51–9. doi:10.3109/10428199509064922. PMID8580829.
Agematsu K (2000). "Memory B cells and CD27". Histol. Histopathol.15 (2): 573–6. PMID10809378.
van Baarle D, Kostense S, van Oers MH, et al. (2003). "Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue". Trends Immunol.23 (12): 586–91. doi:10.1016/S1471-4906(02)02326-8. PMID12464570.