CLEC4M

C-type lectin domain family 4, member M
PDB rendering based on 1k9j.
Available structures PDB 1K9J, 1SL6, 1XAR, 1XPH, 1Z0Y, 3JQH
Identifiers
Symbols	CLEC4M; CD209L; CD299; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN; MGC129964; MGC47866
External IDs	OMIM: 605872 MGI: 2157947 HomoloGene: 8603 GeneCards: CLEC4M Gene
Gene Ontology Molecular function • receptor activity • sugar binding • mannose binding • ICAM-3 receptor activity • peptide antigen binding • virion binding • metal ion binding Cellular component • extracellular region • intracellular • cytoplasm • plasma membrane • integral to plasma membrane • membrane Biological process • endocytosis • leukocyte cell-cell adhesion • cell-cell recognition • virus-host interaction • virion attachment to host cell surface receptor • viral genome replication • antigen processing and presentation • intracellular signal transduction • interspecies interaction between organisms • innate immune response • intracellular virion transport • peptide antigen transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10332	170779
Ensembl	ENSG00000104938	ENSMUSG00000031495
UniProt	Q9H2X3	Q3UW57
RefSeq (mRNA)	NM_001144904.1	NM_130904.2
RefSeq (protein)	NP_001138376.1	NP_570974.1
Location (UCSC)	Chr 19: 7.83 – 7.83 Mb	Chr 8: 3.87 – 3.88 Mb
PubMed search	[1]	[2]

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Further reading

• Baribaud F, Doms RW, Pöhlmann S (2006). "The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?". Expert Opin. Ther. Targets 6 (4): 423–31. doi:10.1517/14728222.6.4.423. PMID 12223058. 
• Becker Y (2004). "HIV-1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes, but the induced IL-4 synthesis by FcepsilonRI+ hematopoietic cells damages the adaptive immunity--a review, hypothesis, and implications.". Virus Genes 29 (1): 147–65. doi:10.1023/B:VIRU.0000032797.43537.d3. PMID 15215692. 
• Lalor PF, Lai WK, Curbishley SM, et al. (2006). "Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.". World J. Gastroenterol. 12 (34): 5429–39. PMID 17006978. 
• Curtis BM, Scharnowske S, Watson AJ (1992). "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8356–60. doi:10.1073/pnas.89.17.8356. PMC 49917. PMID 1518869. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=49917. 
• Gattegno L, Ramdani A, Jouault T, et al. (1992). "Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1).". AIDS Res. Hum. Retroviruses 8 (1): 27–37. doi:10.1089/aid.1992.8.27. PMID 1736938. 
• Soilleux EJ, Barten R, Trowsdale J (2000). "DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13.". J. Immunol. 165 (6): 2937–42. PMID 10975799. 
• Pöhlmann S, Soilleux EJ, Baribaud F, et al. (2001). "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2670–5. doi:10.1073/pnas.051631398. PMC 30196. PMID 11226297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=30196. 
• Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, et al. (2001). "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.". J. Exp. Med. 193 (6): 671–8. doi:10.1084/jem.193.6.671. PMC 2193415. PMID 11257134. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193415. 
• Mummidi S, Catano G, Lam L, et al. (2001). "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.". J. Biol. Chem. 276 (35): 33196–212. doi:10.1074/jbc.M009807200. PMID 11337487. 
• Mitchell DA, Fadden AJ, Drickamer K (2001). "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.". J. Biol. Chem. 276 (31): 28939–45. doi:10.1074/jbc.M104565200. PMID 11384997. 
• Feinberg H, Mitchell DA, Drickamer K, Weis WI (2002). "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.". Science 294 (5549): 2163–6. doi:10.1126/science.1066371. PMID 11739956. 
• Alvarez CP, Lasala F, Carrillo J, et al. (2002). "C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.". J. Virol. 76 (13): 6841–4. doi:10.1128/JVI.76.13.6841-6844.2002. PMC 136246. PMID 12050398. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=136246. 
• Soilleux EJ, Morris LS, Rushbrook S, et al. (2002). "Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity.". Hum. Pathol. 33 (6): 652–9. doi:10.1053/hupa.2002.124036. PMID 12152166. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Lin G, Simmons G, Pöhlmann S, et al. (2003). "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.". J. Virol. 77 (2): 1337–46. doi:10.1128/JVI.77.2.1337-1346.2003. PMC 140807. PMID 12502850. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140807. 
• Pöhlmann S, Zhang J, Baribaud F, et al. (2003). "Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.". J. Virol. 77 (7): 4070–80. doi:10.1128/JVI.77.7.4070-4080.2003. PMC 150620. PMID 12634366. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150620. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Engering A, van Vliet SJ, Hebeda K, et al. (2004). "Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes.". Am. J. Pathol. 164 (5): 1587–95. doi:10.1016/S0002-9440(10)63717-0. PMC 1615649. PMID 15111305. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1615649. 

External links

• MeSH CLEC4M+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.