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CD2-associated protein
Protein CD2AP PDB 2j6f.png
PDB rendering based on 2j6f.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CD2AP ; CMS
External IDs OMIM604241 MGI1330281 HomoloGene7663 GeneCards: CD2AP Gene
Species Human Mouse
Entrez 23607 12488
Ensembl ENSG00000198087 ENSMUSG00000061665
UniProt Q9Y5K6 Q9JLQ0
RefSeq (mRNA) NM_012120 NM_009847
RefSeq (protein) NP_036252 NP_033977
Location (UCSC) Chr 6:
47.45 – 47.59 Mb
Chr 17:
42.79 – 42.88 Mb
PubMed search [1] [2]

CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.[1][2]

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.[2]


CD2AP has been shown to interact with NPHS2,[3] Nephrin,[4] Cbl gene[5][6][7] and RAB4A.[7]

See also[edit]


  1. ^ Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H (Jun 1999). "CMS: An adapter molecule involved in cytoskeletal rearrangements". Proc Natl Acad Sci USA 96 (11): 6211–6. doi:10.1073/pnas.96.11.6211. PMC 26861. PMID 10339567. 
  2. ^ a b "Entrez Gene: CD2AP CD2-associated protein". 
  3. ^ Schwarz, K; Simons M; Reiser J; Saleem M A; Faul C; Kriz W; Shaw A S; Holzman L B; Mundel P (Dec 2001). "Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin". J. Clin. Invest. (United States) 108 (11): 1621–9. doi:10.1172/JCI12849. ISSN 0021-9738. PMC 200981. PMID 11733557. 
  4. ^ Lehtonen, Sanna; Lehtonen Eero; Kudlicka Krystyna; Holthöfer Harry; Farquhar Marilyn G (Sep 2004). "Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin". Am. J. Pathol. (United States) 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. ISSN 0002-9440. PMC 1618613. PMID 15331416. 
  5. ^ Haglund, Kaisa; Ivankovic-Dikic Inga, Shimokawa Noriaki, Kruh Gary D, Dikic Ivan (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell. Sci. (England) 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. ISSN 0021-9533. PMID 15128873. 
  6. ^ Kirsch, K H; Georgescu M M; Shishido T; Langdon W Y; Birge R B; Hanafusa H (Feb 2001). "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction". J. Biol. Chem. (United States) 276 (7): 4957–63. doi:10.1074/jbc.M005784200. ISSN 0021-9258. PMID 11067845. 
  7. ^ a b Cormont, Mireille; Metón Isidoro, Mari Muriel, Monzo Pascale, Keslair Frédérique, Gaskin Chantell, McGraw Timothy E, Le Marchand-Brustel Yannick (Feb 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". Traffic (Denmark) 4 (2): 97–112. doi:10.1034/j.1600-0854.2003.40205.x. ISSN 1398-9219. PMID 12559036. 

Further reading[edit]