CD32

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This article is about the molecule. For the video game console, see Amiga CD32.
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Identifiers
Symbol FCGR2A
Alt. symbols FCG2, FCGR2A1, FCGR2
Entrez 2212
HUGO 3616
OMIM 146790
RefSeq NM_021642
UniProt P12318
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIb, receptor (CD32)
CD32ray.png
Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).[1]
Identifiers
Symbol FCGR2B
Alt. symbols FCG2, FCGR2
Entrez 2213
HUGO 3618
OMIM 604590
RefSeq NM_004001
UniProt P31994
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Identifiers
Symbol FCGR2C
Entrez 9103
HUGO 15626
RefSeq NM_201563
UniProt P31995
Other data
Locus Chr. 1 q23

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.

It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body.[2]

Monoclonal antibodies can distinguish between CD32A and CD32B.[3]

References[edit]

  1. ^ PDB 2FCB; Sondermann P, Huber R, Jacob U. (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577. ; rendered via PyMOL.
  2. ^ Coico, R., Sunshine, G., and Benjamin, E. (2003). "Immunology: A Short Course" p.97.
  3. ^ Veri MC, Gorlatov S, Li H, et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079. 

External links[edit]