CD33

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CD33 molecule
Identifiers
Symbol CD33
Alt. symbols SIGLEC3, SIGLEC-3, gp67
Entrez 945
HUGO 1659
OMIM 159590
RefSeq NM_023068
UniProt P20138
Other data
Locus Chr. 19 q13.3

CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage.[1] It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.[2]

It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

Structure[edit]

The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity.[3]

Clinical significance[edit]

CD33 was the target of gemtuzumab ozogamicin,[4] a monoclonal antibody-based treatment for acute myeloid leukemia, (treatment voluntarily withdrawn from the market in 2010). However, Anti-CD33 monoclonal antibodies are extensively used for the diagnosis of all types of AMLs.[5]

References[edit]