CD33
| CD33 molecule | |
|---|---|
| Identifiers | |
| Symbol | CD33 |
| Alt. symbols | SIGLEC3, SIGLEC-3, gp67 |
| Entrez | 945 |
| HUGO | 1659 |
| OMIM | 159590 |
| RefSeq | NM_023068 |
| UniProt | P20138 |
| Other data | |
| Locus | Chr. 19 q13.3 |
CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage.[1] It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.[2]
It binds sialic acids, therefore is a member of the SIGLEC family of lectins.
Structure[edit]
The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity.[3]
Clinical significance[edit]
CD33 was the target of gemtuzumab ozogamicin,[4] a monoclonal antibody-based treatment for acute myeloid leukemia, (treatment voluntarily withdrawn from the market in 2010).[5]
References[edit]
- ^ Garnache-Ottou F, Chaperot L, Biichle S, et al. (February 2005). "Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells". Blood 105 (3): 1256–64. doi:10.1182/blood-2004-06-2416. PMID 15388576.
- ^ Hernández-Caselles T, Martínez-Esparza M, Pérez-Oliva AB, et al. (January 2006). "A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing". J. Leukoc. Biol. 79 (1): 46–58. doi:10.1189/jlb.0205096. PMID 16380601.
- ^ Myeloid cell surface antigen CD33 precursor - Homo sapiens (Human)
- ^ Walter RB, Gooley TA, van der Velden VH, et al. (May 2007). "CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy". Blood 109 (10): 4168–70. doi:10.1182/blood-2006-09-047399. PMC 1885511. PMID 17227830.
- ^ [1]
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