CD33

CD33 molecule
Identifiers
Symbol	CD33
Alt. symbols	SIGLEC3, SIGLEC-3, gp67
Entrez	945
HUGO	1659
OMIM	159590
RefSeq	NM_023068
UniProt	P20138
Other data
Locus	Chr. 19 q13.3

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CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage.^[1] It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.^[2]

It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

[edit] Structure

The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity.^[3]

[edit] Clinical significance

CD33 is the target of gemtuzumab ozogamicin,^[4] a monoclonal antibody-based treatment for acute myeloid leukemia.

[edit] References

^ Garnache-Ottou F, Chaperot L, Biichle S, et al. (February 2005). "Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells". Blood 105 (3): 1256–64. doi:10.1182/blood-2004-06-2416. PMID 15388576. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=15388576.
^ Hernández-Caselles T, Martínez-Esparza M, Pérez-Oliva AB, et al. (January 2006). "A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing". J. Leukoc. Biol. 79 (1): 46–58. doi:10.1189/jlb.0205096. PMID 16380601. http://www.jleukbio.org/cgi/pmidlookup?view=long&pmid=16380601.
^ Myeloid cell surface antigen CD33 precursor - Homo sapiens (Human)
^ Walter RB, Gooley TA, van der Velden VH, et al. (May 2007). "CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy". Blood 109 (10): 4168–70. doi:10.1182/blood-2006-09-047399. PMC 1885511. PMID 17227830. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=17227830.

This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid15388576-0] Garnache-Ottou F, Chaperot L, Biichle S, et al. (February 2005). "Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells". Blood 105 (3): 1256–64. doi:10.1182/blood-2004-06-2416. PMID 15388576. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=15388576.

[pmid16380601-1] Hernández-Caselles T, Martínez-Esparza M, Pérez-Oliva AB, et al. (January 2006). "A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing". J. Leukoc. Biol. 79 (1): 46–58. doi:10.1189/jlb.0205096. PMID 16380601. http://www.jleukbio.org/cgi/pmidlookup?view=long&pmid=16380601.

[2] Myeloid cell surface antigen CD33 precursor - Homo sapiens (Human)

[pmid17227830-3] Walter RB, Gooley TA, van der Velden VH, et al. (May 2007). "CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy". Blood 109 (10): 4168–70. doi:10.1182/blood-2006-09-047399. PMC 1885511. PMID 17227830. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=17227830.

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CD33

[edit] Structure

[edit] Clinical significance

[edit] References

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