The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.
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Okochi H; Mine T; Nashiro K et al. (1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". J. Clin. Gastroenterol.29 (1): 63–67. doi:10.1097/00004836-199907000-00016. PMID10405235.Cite uses deprecated parameter |author-separator= (help)
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van Spriel AB; Puls KL; Sofi M et al. (2004). "A regulatory role for CD37 in T cell proliferation". J. Immunol.172 (5): 2953–61. doi:10.4049/jimmunol.172.5.2953. PMID14978098.Cite uses deprecated parameter |author-separator= (help)