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CD37 molecule
Symbols CD37 ; GP52-40; TSPAN26
External IDs OMIM151523 MGI88330 HomoloGene20422 GeneCards: CD37 Gene
RNA expression pattern
PBB GE CD37 204192 at tn.png
More reference expression data
Species Human Mouse
Entrez 951 12493
Ensembl ENSG00000104894 ENSMUSG00000030798
UniProt P11049 Q61470
RefSeq (mRNA) NM_001040031 NM_001290802
RefSeq (protein) NP_001035120 NP_001277731
Location (UCSC) Chr 19:
49.84 – 49.85 Mb
Chr 7:
45.23 – 45.24 Mb
PubMed search [1] [2]

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.[2]

See also[edit]


  1. ^ Virtaneva KI, Angelisova P, Baumruker T, Horejsi V, Nevanlinna H, Schroder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics 37 (6): 461–465. doi:10.1007/BF00222471. PMID 8436422. 
  2. ^ a b "Entrez Gene: CD37 CD37 molecule". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.