CD37

CD37 molecule
Identifiers
Symbols	CD37; GP52-40; MGC120234; TSPAN26
External IDs	OMIM: 151523 MGI: 88330 HomoloGene: 20422 GeneCards: CD37 Gene
Gene Ontology Cellular component • membrane • integral to membrane Biological process • positive regulation of immunoglobulin production • regulation of humoral immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	951	12493
Ensembl	ENSG00000104894	ENSMUSG00000030798
UniProt	P11049	Q3U1W9
RefSeq (mRNA)	NM_001040031.1	NM_007645.4
RefSeq (protein)	NP_001035120.1	NP_031671.1
Location (UCSC)	Chr 19: 49.84 – 49.84 Mb	Chr 7: 52.49 – 52.49 Mb
PubMed search	[1]	[2]

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.

See also

• Cluster of differentiation

Further reading

• Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Lett. 288 (1–2): 1–4. doi:10.1016/0014-5793(91)80988-F. PMID 1879540. 
• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647. 
• Classon BJ, Williams AF, Willis AC et al (1990). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". J. Exp. Med. 172 (3): 1007–1007. doi:10.1084/jem.172.3.1007. PMC 2188538. PMID 2388030. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2188538. 
• Classon BJ, Williams AF, Willis AC et al (1989). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". J. Exp. Med. 169 (4): 1497–1502. doi:10.1084/jem.169.4.1497. PMC 2189247. PMID 2466944. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2189247. 
• Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G (1988). "The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein". J. Immunol. 140 (3): 905–14. PMID 3257508. 
• Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins". Immunogenetics 39 (4): 249–56. doi:10.1007/BF00188787. PMID 8119731. 
• Wright MD, Rochelle JM, Tomlinson MG et al (1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". Int. Immunol. 5 (2): 209–216. doi:10.1093/intimm/5.2.209. PMID 8452817. 
• Serru V, Le Naour F, Billard M et al (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220227. 
• Okochi H, Mine T, Nashiro K et al (1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". J. Clin. Gastroenterol. 29 (1): 63–67. doi:10.1097/00004836-199907000-00016. PMID 10405235. 
• Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T (1999). "Functional expression of transmembrane 4 superfamily molecules on human eosinophils". Int. Arch. Allergy Immunol. 120 Suppl 1: 38–44. doi:10.1159/000053592. PMID 10529602. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• van Spriel AB, Puls KL, Sofi M et al (2004). "A regulatory role for CD37 in T cell proliferation". J. Immunol. 172 (5): 2953–61. PMID 14978098. 
• Suzuki Y, Yamashita R, Shirota M et al (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Meyer-Wentrup F, Figdor CG, Ansems M et al (2007). "Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production". J. Immunol. 178 (1): 154–62. PMID 17182550. 
• Zhao X, Lapalombella R, Joshi T et al (2007). "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical". Blood 110 (7): 2569–2577. doi:10.1182/blood-2006-12-062927. PMC 1988922. PMID 17440052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1988922. 

External links

• MeSH CD37+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.