CD37

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CD37 molecule
Identifiers
Symbols CD37 ; GP52-40; TSPAN26
External IDs OMIM151523 MGI88330 HomoloGene20422 GeneCards: CD37 Gene
RNA expression pattern
PBB GE CD37 204192 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 951 12493
Ensembl ENSG00000104894 ENSMUSG00000030798
UniProt P11049 Q61470
RefSeq (mRNA) NM_001040031 NM_007645
RefSeq (protein) NP_001035120 NP_031671
Location (UCSC) Chr 19:
49.84 – 49.85 Mb
Chr 7:
45.23 – 45.24 Mb
PubMed search [1] [2]

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.[2]

See also[edit]

References[edit]

  1. ^ Virtaneva KI, Angelisova P, Baumruker T, Horejsi V, Nevanlinna H, Schroder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics 37 (6): 461–465. doi:10.1007/BF00222471. PMID 8436422. 
  2. ^ a b "Entrez Gene: CD37 CD37 molecule". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.