CD48

CD48 molecule
Identifiers
Symbols	CD48; BCM1; BLAST; BLAST1; MEM-102; SLAMF2; hCD48; mCD48
External IDs	OMIM: 109530 MGI: 88339 HomoloGene: 1347 GeneCards: CD48 Gene
Gene Ontology Molecular function • antigen binding • protein binding Cellular component • plasma membrane • integral to plasma membrane • protein complex • membrane raft • anchored to plasma membrane Biological process • defense response • blood coagulation • mast cell activation • leukocyte migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	962	12506
Ensembl	ENSG00000117091	ENSMUSG00000015355
UniProt	P09326	Q9R1N8
RefSeq (mRNA)	NM_001778	NM_007649.4
RefSeq (protein)	NP_001769	NP_031675.1
Location (UCSC)	Chr 1: 160.65 – 160.68 Mb	Chr 1: 173.61 – 173.64 Mb
PubMed search	[1]	[2]

CD48 (Cluster of Differentiation 48) is a human protein encoded by the CD48 gene.

See also

• Cluster of differentiation

Further reading

• Shin JS, Abraham SN (2001). "Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis.". FEMS Microbiol. Lett. 197 (2): 131–8. doi:10.1111/j.1574-6968.2001.tb10594.x. PMID 11313125. 
• Wong YW, Williams AF, Kingsmore SF, Seldin MF (1990). "Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3". J. Exp. Med. 171 (6): 2115–30. doi:10.1084/jem.171.6.2115. PMC 2187942. PMID 1693656. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2187942. 
• Del Porto P, Mami-Chouaib F, Bruneau JM et al (1991). "TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1". J. Exp. Med. 173 (6): 1339–44. doi:10.1084/jem.173.6.1339. PMC 2190850. PMID 1827826. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2190850. 
• Fisher RC, Thorley-Lawson DA (1991). "Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48)". Mol. Cell. Biol. 11 (3): 1614–23. PMC 369456. PMID 1847502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=369456. 
• Korínek V, Stefanová I, Angelisová P et al (1991). "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1". Immunogenetics 33 (2): 108–12. doi:10.1007/BF00210823. PMID 1999350. 
• Vaughan HA, Henning MM, Purcell DF et al (1991). "The isolation of cDNA clones for CD48". Immunogenetics 33 (2): 113–7. doi:10.1007/BF00210824. PMID 1999351. 
• Staunton DE, Thorley-Lawson DA (1988). "Molecular cloning of the lymphocyte activation marker Blast-1". EMBO J. 6 (12): 3695–701. PMC 553839. PMID 2828034. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=553839. 
• Garnett D, Barclay AN, Carmo AM, Beyers AD (1993). "The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation". Eur. J. Immunol. 23 (10): 2540–4. doi:10.1002/eji.1830231024. PMID 8104794. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Solomon KR, Rudd CE, Finberg RW (1996). "The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 93 (12): 6053–8. doi:10.1073/pnas.93.12.6053. PMC 39187. PMID 8650218. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39187. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Smith GM, Biggs J, Norris B et al (1998). "Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis". J. Clin. Immunol. 17 (6): 502–9. doi:10.1023/A:1027327912204. PMID 9418191. 
• Latchman Y, McKay PF, Reiser H (1998). "Identification of the 2B4 molecule as a counter-receptor for CD48". J. Immunol. 161 (11): 5809–12. PMID 9834056. 
• Nakajima H, Cella M, Langen H et al (1999). "Activating interactions in human NK cell recognition: the role of 2B4-CD48". Eur. J. Immunol. 29 (5): 1676–83. doi:10.1002/(SICI)1521-4141(199905)29:05<1676::AID-IMMU1676>3.0.CO;2-Y. PMID 10359122. 
• Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells". Mol. Immunol. 37 (9): 493–501. doi:10.1016/S0161-5890(00)00076-6. PMID 11163399. 
• Suzuki T, Kiyokawa N, Taguchi T et al (2001). "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system". J. Immunol. 166 (9): 5567–77. PMID 11313396. 
• Hawash IY, Hu XE, Adal A et al (2002). "The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling". Biochim. Biophys. Acta 1589 (2): 140–50. doi:10.1016/S0167-4889(02)00165-9. PMID 12007789. 
• Kim D, Hur DY, Kim YS et al (2002). "CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cells". Hum. Immunol. 63 (7): 576–87. doi:10.1016/S0198-8859(02)00405-6. PMID 12072193. 
• Zhu B, Davies EA, van der Merwe PA et al (2002). "Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48". Biochemistry 41 (40): 12163–70. doi:10.1021/bi020296g. PMID 12356317. 

External links

• MeSH CD48+protein,+human