CD49a

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Integrin, alpha 1
Protein ITGA1 PDB 1ck4.png
PDB rendering based on 1ck4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGA1 ; CD49a; VLA1
External IDs OMIM192968 MGI96599 HomoloGene57137 ChEMBL: 3682 GeneCards: ITGA1 Gene
Orthologs
Species Human Mouse
Entrez 3672 109700
Ensembl ENSG00000213949 ENSMUSG00000042284
UniProt P56199 Q3V3R4
RefSeq (mRNA) NM_181501 NM_001033228
RefSeq (protein) NP_852478 NP_001028400
Location (UCSC) Chr 5:
52.08 – 52.25 Mb
Chr 13:
114.96 – 115.1 Mb
PubMed search [1] [2]

CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[1]

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