CD49a

Integrin, alpha 1
	; PDB rendering based on 1ck4.
Available structures
PDB	1PT6, 1QC5, 1QCY
Identifiers
Symbols	ITGA1; CD49a; VLA1
External IDs	OMIM: 192968 MGI: 96599 HomoloGene: 57137 GeneCards: ITGA1 Gene
Gene Ontology
Molecular function	• receptor activity; • integrin binding; • protein binding; • collagen binding; • protein heterodimerization activity;
Cellular component	• acrosomal vesicle; • membrane fraction; • plasma membrane; • integrin complex; • external side of plasma membrane; • integral to membrane; • neuron projection; • perikaryon; • membrane raft;
Biological process	• activation of MAPK activity; • muscle contraction; • cell adhesion; • cell-matrix adhesion; • integrin-mediated signaling pathway; • axon guidance; • vasodilation; • positive regulation of neuron apoptosis; • neuron projection morphogenesis; • cell chemotaxis;
	Sources: Amigo / QuickGO
Orthologs

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CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.^[1]

[edit] References

^ "Entrez Gene: ITGA1 integrin, alpha 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3672.

[edit] Further reading

Virtanen I, Korhonen M, Kariniemi AL, et al. (1991). "Integrins in human cells and tumors.". Cell Differ. Dev. 32 (3): 215–27. doi:10.1016/0922-3371(90)90034-T. PMID 2099238.
Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis.". Atherosclerosis 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture.". J. Cell. Sci. 103 (1): 267–71. PMID 1429908.
Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.". J. Biol. Chem. 265 (11): 5938–41. PMID 1690718.
Sonnenberg A, Linders CJ, Modderman PW, et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.". J. Cell Biol. 110 (6): 2145–55. doi:10.1083/jcb.110.6.2145. PMC 2116116. PMID 1693624. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2116116.
Belkin VM, Belkin AM, Dol'nikova AE, et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia 56 (12): 2198–206. PMID 1807406.
Bank I, Roth D, Book M, et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases.". J. Clin. Immunol. 11 (1): 29–38. doi:10.1007/BF00918792. PMID 1827128.
Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium.". J. Clin. Endocrinol. Metab. 71 (3): 645–9. doi:10.1210/jcem-71-3-645. PMID 2144294.
Tawil NJ, Houde M, Blacher R, et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells.". Biochemistry 29 (27): 6540–4. doi:10.1021/bi00479a028. PMC 2710132. PMID 2169872. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2710132.
Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development.". J. Cell Biol. 111 (5 Pt 1): 2159–70. doi:10.1083/jcb.111.5.2159. PMC 2116325. PMID 2229189. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2116325.
MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine.". J. Clin. Pathol. 43 (4): 313–5. doi:10.1136/jcp.43.4.313. PMC 502365. PMID 2341567. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=502365.
Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239–43. doi:10.1073/pnas.84.10.3239. PMC 304844. PMID 3033641. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=304844.
Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.". J. Biol. Chem. 262 (7): 3300–9. PMID 3546305.
Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system.". Exp. Cell Res. 221 (2): 478–85. doi:10.1006/excr.1995.1399. PMID 7493648.
Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk.". Immunol. Cell Biol. 72 (4): 306–13. doi:10.1038/icb.1994.46. PMID 7806264.
Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees.". J. Histochem. Cytochem. 43 (4): 447–57. PMID 7897185.
Pfaff M, Aumailley M, Specks U, et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI.". Exp. Cell Res. 206 (1): 167–76. doi:10.1006/excr.1993.1134. PMID 8387021.
Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit.". J. Biol. Chem. 268 (4): 2989–96. PMID 8428973.
Langholz O, Röckel D, Mauch C, et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins.". J. Cell Biol. 131 (6 Pt 2): 1903–15. doi:10.1083/jcb.131.6.1903. PMC 2120685. PMID 8557756. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120685.