CD49b

Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
PDB rendering based on 1aox.
Available structures PDB 1AOX, 1DZI, 1PQB, 1V7P
Identifiers
Symbols	ITGA2; BR; CD49B; GPIa; VLA-2; VLAA2
External IDs	OMIM: 192974 MGI: 96600 HomoloGene: 1662 GeneCards: ITGA2 Gene
Gene Ontology Molecular function • receptor activity • protein binding • collagen binding • identical protein binding Cellular component • plasma membrane • plasma membrane • integrin complex • external side of plasma membrane • cell surface • integral to membrane Biological process • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • axon guidance • blood coagulation • organ morphogenesis • interspecies interaction between organisms Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3673	16398
Ensembl	ENSG00000164171	ENSMUSG00000015533
UniProt	P17301	Q6P1C7
RefSeq (mRNA)	NM_002203.3	NM_008396.2
RefSeq (protein)	NP_002194.2	NP_032422.2
Location (UCSC)	Chr 5: 52.29 – 52.39 Mb	Chr 13: 115.63 – 115.72 Mb
PubMed search	[1]	[2]

CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene.

The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.

DX5 is a monoclonal antibody which binds to CD49b.

External links

• MeSH CD49b+antigen

Interactions

CD49b has been shown to interact with MMP1.

Further reading

• Moroi M, Jung SM (1997). "Platelet receptors for collagen.". Thromb. Haemost. 78 (1): 439–44. PMID 9198193. 
• Takada Y, Kamata T, Irie A, et al. (1998). "Structural basis of integrin-mediated signal transduction.". Matrix Biol. 16 (4): 143–51. doi:10.1016/S0945-053X(97)90002-0. PMID 9402003. 
• Dickeson SK, Santoro SA (1998). "Ligand recognition by the I domain-containing integrins.". Cell. Mol. Life Sci. 54 (6): 556–66. doi:10.1007/s000180050184. PMID 9676575. 
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327. 
• Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis.". Atherosclerosis 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545. 
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.". Italian heart journal : official journal of the Italian Federation of Cardiology 4 (1): 17–22. PMID 12690916. 
• Tsantes AE, Nikolopoulos GK, Bagos PG, et al. (2007). "Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis.". Int. J. Cardiol. 118 (2): 189–96. doi:10.1016/j.ijcard.2006.06.047. PMID 17023078. 

External links

• ITGA2 Info with links in the Cell Migration Gateway