CD49c

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Identifiers
Symbols	ITGA3; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a
External IDs	OMIM: 605025 MGI: 96602 HomoloGene: 21129 GeneCards: ITGA3 Gene
Gene Ontology
Molecular function	• receptor activity; • protein binding;
Cellular component	• plasma membrane; • plasma membrane; • integrin complex; • cell surface; • integral to membrane; • basolateral plasma membrane; • synaptosome;
Biological process	• neuron migration; • cell adhesion; • cell-matrix adhesion; • integrin-mediated signaling pathway; • blood coagulation; • memory; • leukocyte migration;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.^[1]^[2] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

[edit] Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').^[3]

[edit] Interactions

CD49c has been shown to interact with TSPAN4,^[4] LGALS8,^[5] CD9^[6]^[7] and FHL2.^[8]

[edit] References

^ Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (Oct 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol 115 (1): 257–66. doi:10.1083/jcb.115.1.257. PMC 2289928. PMID 1655803. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2289928.
^ Jones SD, van der Flier A, Sonnenberg A (Sep 1998). "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun 248 (3): 896–8. doi:10.1006/bbrc.1998.9071. PMID 9704023.
^ "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3675.
^ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (Nov. 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996.
^ Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul. 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. (ENGLAND) 113 (13): 2385–97. ISSN 0021-9533. PMID 10852818.
^ Park, K R; Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S (Mar. 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. (ENGLAND) 6 (3): 252–7. doi:10.1093/molehr/6.3.252. ISSN 1360-9947. PMID 10694273.
^ Hirano, T; Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (Feb. 1999). "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. (ENGLAND) 5 (2): 162–7. doi:10.1093/molehr/5.2.162. ISSN 1360-9947. PMID 10065872.
^ Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct. 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.

[edit] Further reading

Bosman FT (1993). "Integrins: cell adhesives and modulators of cell function.". Histochem. J. 25 (7): 469–77. doi:10.1007/BF00159282. PMID 8407358.
Fornaro M, Languino LR (1998). "Alternatively spliced variants: a new view of the integrin cytoplasmic domain.". Matrix Biol. 16 (4): 185–93. doi:10.1016/S0945-053X(97)90007-X. PMID 9402008.

[edit] External links

MeSH CD49c+antigen
ITGA3 Info with links in the Cell Migration Gateway

This immunology article is a stub. You can help Wikipedia by expanding it.

[pmid1655803-0] Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (Oct 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol 115 (1): 257–66. doi:10.1083/jcb.115.1.257. PMC 2289928. PMID 1655803. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2289928.

[pmid9704023-1] Jones SD, van der Flier A, Sonnenberg A (Sep 1998). "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun 248 (3): 896–8. doi:10.1006/bbrc.1998.9071. PMID 9704023.

[2] "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3675.

[pmid9360996-3] Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (Nov. 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996.

[pmid10852818-4] Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul. 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. (ENGLAND) 113 (13): 2385–97. ISSN 0021-9533. PMID 10852818.

[pmid10694273-5] Park, K R; Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S (Mar. 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. (ENGLAND) 6 (3): 252–7. doi:10.1093/molehr/6.3.252. ISSN 1360-9947. PMID 10694273.

[pmid10065872-6] Hirano, T; Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (Feb. 1999). "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. (ENGLAND) 5 (2): 162–7. doi:10.1093/molehr/5.2.162. ISSN 1360-9947. PMID 10065872.

[pmid10906324-7] Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct. 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.

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CD49c

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