CD49d

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Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGA4 ; CD49D; IA4
External IDs OMIM192975 MGI96603 HomoloGene37364 ChEMBL: 278 GeneCards: ITGA4 Gene
RNA expression pattern
PBB GE ITGA4 213416 at tn.png
PBB GE ITGA4 205884 at tn.png
PBB GE ITGA4 205885 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3676 16401
Ensembl ENSG00000115232 ENSMUSG00000027009
UniProt P13612 Q00651
RefSeq (mRNA) NM_000885 NM_010576
RefSeq (protein) NP_000876 NP_034706
Location (UCSC) Chr 2:
182.32 – 182.4 Mb
Chr 2:
79.26 – 79.33 Mb
PubMed search [1] [2]

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

Function[edit]

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.[1]

Interactions[edit]

CD49d has been shown to interact with LGALS8[2] and Paxillin.[3][4]

References[edit]

  1. ^ "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". 
  2. ^ Hadari Y, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R et al. (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. 113 (Pt 13): 2385–97. PMID 10852818. 
  3. ^ Han J, Liu S, Rose D, Schlaepfer D, McDonald H, Ginsberg M (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. doi:10.1074/jbc.M102665200. PMID 11533025. 
  4. ^ Liu S, Kiosses W, Rose D, Slepak M, Salgia R, Griffin J et al. (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. doi:10.1074/jbc.M110928200. PMID 11919182. 

Further reading[edit]

External links[edit]