CD52
From Wikipedia, the free encyclopedia
| CD52 molecule | |
|---|---|
| Identifiers | |
| Symbol | CD52 |
| Alt. symbols | CDW52 |
| Entrez | 1043 |
| HUGO | 1804 |
| OMIM | 114280 |
| RefSeq | NM_001803 |
| UniProt | P31358 |
| Other data | |
| Locus | Chr. 1 p36 |
CD52 is a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived.
It also is found in monocytes[1] and dendritic cells.[2]
It is a glycosylphosphatidylinositol (GPI)--anchored antigen expressed on the all lymphocytes as well as within the male genital tract.
[edit] Clinical significance
It is associated with certain types of lymphoma.[3]
It is the protein targeted by alemtuzumab, an antibody used for the treatment of chronic lymphocytic leukemia and currently being evaluated in a phase III clinical trial for the treatment of multiple sclerosis.
[edit] References
- ^ Buggins AG, Mufti GJ, Salisbury J, et al. (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood 100 (5): 1715–20. PMID 12176892. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12176892.
- ^ Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12393688.
- ^ Piccaluga PP, Agostinelli C, Righi S, Zinzani PL, Pileri SA (2007). "Expression of CD52 in peripheral T-cell lymphoma". Haematologica 92 (4): 566–7. doi:10.3324/haematol.10767. PMID 17488672.
[edit] External links
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