CD6

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CD6 molecule
Identifiers
Symbols CD6 ; TP120
External IDs OMIM186720 MGI103566 HomoloGene4893 GeneCards: CD6 Gene
Orthologs
Species Human Mouse
Entrez 923 12511
Ensembl ENSG00000013725 ENSMUSG00000024670
UniProt P30203 Q61003
RefSeq (mRNA) NM_001254750 NM_001037801
RefSeq (protein) NP_001241679 NP_001032890
Location (UCSC) Chr 11:
60.74 – 60.79 Mb
Chr 19:
10.79 – 10.83 Mb
PubMed search [1] [2]

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.[1][2]

Function[edit]

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.[1]

Clinical significance[edit]

Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.[3][4]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: CD6 CD6 molecule". 
  2. ^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007. 
  3. ^ De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet. 41 (7): 776–82. doi:10.1038/ng.401. PMC 2757648. PMID 19525953. 
  4. ^ Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA (2011). "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation". J. Immunol. 187 (6): 3286–91. doi:10.4049/jimmunol.1100626. PMID 21849685. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.