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CD7 molecule
Symbols CD7 ; GP40; LEU-9; TP41; Tp40
External IDs OMIM186820 MGI88344 HomoloGene4471 GeneCards: CD7 Gene
RNA expression pattern
PBB GE CD7 214551 s at tn.png
PBB GE CD7 214049 x at tn.png
More reference expression data
Species Human Mouse
Entrez 924 12516
Ensembl ENSG00000173762 ENSMUSG00000025163
UniProt P09564 P50283
RefSeq (mRNA) NM_006137 NM_009854
RefSeq (protein) NP_006128 NP_033984
Location (UCSC) Chr 17:
80.27 – 80.28 Mb
Chr 11:
121.04 – 121.04 Mb
PubMed search [1] [2]

CD7 (Cluster of Differentiation 7) is a human protein encoded by the CD7 gene.[1]

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[1]

See also[edit]


CD7 has been shown to interact with PIK3R1.[2][3]

Clinical importance[edit]

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis. Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary Syndrome (SS).


  1. ^ a b "Entrez Gene: CD7 CD7 molecule". 
  2. ^ Lee, D M; Patel D D; Pendergast A M; Haynes B F (Aug 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". Int. Immunol. (ENGLAND) 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. ISSN 0953-8178. PMID 8918688. 
  3. ^ Subrahmanyam, Gosukonda; Rudd Christopher E; Schneider Helga (Jan 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". Eur. J. Immunol. (Germany) 33 (1): 46–52. doi:10.1002/immu.200390006. ISSN 0014-2980. PMID 12594831. 

Further reading[edit]

External links[edit]