CD7

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CD7 molecule
Identifiers
Symbols CD7 ; GP40; LEU-9; TP41; Tp40
External IDs OMIM186820 MGI88344 HomoloGene4471 GeneCards: CD7 Gene
RNA expression pattern
PBB GE CD7 214551 s at tn.png
PBB GE CD7 214049 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 924 12516
Ensembl ENSG00000173762 ENSMUSG00000025163
UniProt P09564 P50283
RefSeq (mRNA) NM_006137 NM_009854
RefSeq (protein) NP_006128 NP_033984
Location (UCSC) Chr 17:
80.27 – 80.28 Mb
Chr 11:
121.04 – 121.04 Mb
PubMed search [1] [2]

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[1]

Function[edit]

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[1]

See also[edit]

Interactions[edit]

CD7 has been shown to interact with PIK3R1.[2][3]

Clinical significance[edit]

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[4] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[5]

References[edit]

  1. ^ a b "Entrez Gene: CD7 CD7 molecule". 
  2. ^ Lee DM, Patel DD, Pendergast AM, Haynes BF (Aug 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". Int. Immunol. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688. 
  3. ^ Subrahmanyam G, Rudd CE, Schneider H (Jan 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". Eur. J. Immunol. 33 (1): 46–52. doi:10.1002/immu.200390006. PMID 12594831. 
  4. ^ Yasuko Hamada, Hideto Tamura, Mariko Ishibashi, Namiko Okuyama, Asaka Kondo, Keiichi Moriya, Kiyoyuki Ogata, Keiji Kakumoto, Yoshihide Miyazaki, Akira Matsuda, Kaoru Tohyama, Yasunori Ueda, Mineo Kurokawa, Hirohiko Shibayama, Nobuhiko Emi, Kinuko Mitani, Tomoki Naoe, Haruo Sugiyama, Koiti Inokuchi (2013). "CD7 Expression On Blasts Of Myelodysplastic Syndromes Is Associated With Apoptosis Resistance With Decreased Expression Of The Proapoptotic Protein Bad and An Independent Unfavorable Prognostic Factor Together With The Revised IPSS Score In Patients". Blood 122 (21): 2799. 
  5. ^ Stevens SR, Baron ED, Masten S, Cooper KD (2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Arch Dermatol 138 (10): 1347–50. PMID 12374541. 

Further reading[edit]

External links[edit]