CD80

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CD80 molecule
PDB 1dr9 EBI.jpg
Rendering of 1DR9
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CD80 ; B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7
External IDs OMIM112203 MGI101775 HomoloGene3804 GeneCards: CD80 Gene
Orthologs
Species Human Mouse
Entrez 941 12519
Ensembl ENSG00000121594 ENSMUSG00000075122
UniProt P33681 Q00609
RefSeq (mRNA) NM_005191 NM_009855
RefSeq (protein) NP_005182 NP_033985
Location (UCSC) Chr 3:
119.24 – 119.28 Mb
Chr 16:
38.46 – 38.49 Mb
PubMed search [1] [2]

Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4[1][2] (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.

See also[edit]

References[edit]

  1. ^ Peach, R J; Bajorath J; Naemura J; Leytze G; Greene J; Aruffo A; Linsley P S (Sep 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. (UNITED STATES) 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. ISSN 0021-9258. PMID 7545666. 
  2. ^ Stamper, C C; Zhang Y; Tobin J F; Erbe D V; Ikemizu S; Davis S J; Stahl M L; Seehra J; Somers W S; Mosyak L (Mar 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses". Nature (England) 410 (6828): 608–11. doi:10.1038/35069118. ISSN 0028-0836. PMID 11279502. 

Further reading[edit]

  • Weitzmann MN, Pacifici R (2006). "Estrogen regulation of immune cell bone interactions". Ann. N. Y. Acad. Sci. 1068: 256–74. doi:10.1196/annals.1346.030. PMID 16831927. 
  • Knolle PA, Gerken G (2000). "Local control of the immune response in the liver.". Immunol. Rev. 174: 21–34. doi:10.1034/j.1600-0528.2002.017408.x. PMID 10807504. 
  • Henz BM, Maurer M, Lippert U, et al. (2001). "Mast cells as initiators of immunity and host defense.". Exp. Dermatol. 10 (1): 1–10. doi:10.1034/j.1600-0625.2001.100101.x. PMID 11168574. 
  • Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Curr. Dir. Autoimmun. Current Directions in Autoimmunity 5: 113–30. doi:10.1159/000060550. ISBN 3-8055-7308-1. PMID 11826754. 
  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711. 
  • Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296. 
  • Freeman GJ, Disteche CM, Gribben JG, et al. (1992). "The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21". Blood 79 (2): 489–94. PMID 1370389. 
  • Selvakumar A, Mohanraj BK, Eddy RL, et al. (1992). "Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7". Immunogenetics 36 (3): 175–81. doi:10.1007/BF00661094. PMID 1377173. 
  • Freeman GJ, Gray GS, Gimmi CD, et al. (1991). "Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7". J. Exp. Med. 174 (3): 625–31. doi:10.1084/jem.174.3.625. PMC 2118924. PMID 1714935. 
  • Freeman GJ, Freedman AS, Segil JM, et al. (1989). "B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells". J. Immunol. 143 (8): 2714–22. PMID 2794510. 
  • Weiskirchen R, Pino JD, Macalma T, et al. (1996). "The cysteine-rich protein family of highly related LIM domain proteins". J. Biol. Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425. 
  • Lanier LL, O'Fallon S, Somoza C, et al. (1995). "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL". J. Immunol. 154 (1): 97–105. PMID 7527824. 
  • Chirmule N, McCloskey TW, Hu R, et al. (1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. PMID 7541827. 
  • Peach RJ, Bajorath J, Naemura J, et al. (1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. PMID 7545666. 
  • Tuosto L, Piazza C, Moretti S, et al. (1995). "Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis". Eur. J. Immunol. 25 (10): 2917–22. doi:10.1002/eji.1830251031. PMID 7589092. 
  • Chirmule N, Oyaizu N, Saxinger C, Pahwa S (1994). "Nef protein of HIV-1 has B-cell stimulatory activity". AIDS 8 (6): 733–4. doi:10.1097/00002030-199406000-00002. PMID 8086129. 
  • Weiskirchen R, Bister K (1993). "Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains". Oncogene 8 (9): 2317–24. PMID 8361751. 
  • Dono M, Zupo S, Augliera A, et al. (1996). "Subepithelial B cells in the human palatine tonsil. II. Functional characterization". Eur. J. Immunol. 26 (9): 2043–9. doi:10.1002/eji.1830260912. PMID 8814244. 
  • Reeves RH, Patch D, Sharpe AH, et al. (1997). "The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3". Mamm. Genome 8 (8): 581–2. doi:10.1007/s003359900508. PMID 9250865. 
  • Olivares EG, Montes MJ, Oliver C, et al. (1997). "Cultured human decidual stromal cells express B7-1 (CD80) and B7-2 (CD86) and stimulate allogeneic T cells". Biol. Reprod. 57 (3): 609–15. doi:10.1095/biolreprod57.3.609. PMID 9282998. 
  • Weiskirchen R, Erdel M, Utermann G, Bister K (1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.