CD86

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CD86 molecule

PDB rendering based on 1i85.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CD86 ; B7-2; B7.2; B70; CD28LG2; LAB72
External IDs OMIM601020 MGI101773 HomoloGene10443 GeneCards: CD86 Gene
RNA expression pattern
PBB GE CD86 205686 s at tn.png
PBB GE CD86 205685 at tn.png
PBB GE CD86 210895 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 942 12524
Ensembl ENSG00000114013 ENSMUSG00000022901
UniProt P42081 P42082
RefSeq (mRNA) NM_001206924 NM_019388
RefSeq (protein) NP_001193853 NP_062261
Location (UCSC) Chr 3:
121.77 – 121.84 Mb
Chr 16:
36.6 – 36.67 Mb
PubMed search [1] [2]

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.[1] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.[2]

Clinical significance[edit]

See also[edit]

References[edit]

  1. ^ Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726. 
  2. ^ "Entrez Gene: CD86 CD86 molecule". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.