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CD97 molecule
Protein CD97 PDB 2bo2.png
PDB rendering based on 2bo2.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CD97 ; TM7LN1
External IDs OMIM601211 MGI1347095 HomoloGene8050 IUPHAR: CD97 GeneCards: CD97 Gene
RNA expression pattern
PBB GE CD97 202910 s at tn.png
More reference expression data
Species Human Mouse
Entrez 976 26364
Ensembl ENSG00000123146 ENSMUSG00000002885
UniProt P48960 Q9Z0M6
RefSeq (mRNA) NM_001025160 NM_001163029
RefSeq (protein) NP_001020331 NP_001156501
Location (UCSC) Chr 19:
14.38 – 14.41 Mb
Chr 8:
83.72 – 83.74 Mb
PubMed search [1] [2]

CD97 antigen is a protein that in humans is encoded by the CD97 gene.[1][2][3]

This gene encodes a member of the adhesion-GPCR receptor family [4] expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5] In the case of CD97 the N-terminal domains consist of alternatively spliced epidermal growth factor (EGF)-like domains. These mediate binding to its cellular ligand, decay accelerating factor (DAF/CD55), a regulatory protein of the complement cascade, however the CD55-CD97 interaction is believed to have an activity independent of complement. Alternative splicing has been observed for this gene and three variants have been found.[3]

CD97 is an adhesion GPCR that is normally found on tissue of hematapoetic origin and in smooth muscle.[6] It signals through Gα12/13 and activates RHO. It has been found to be upregulated in Cancers, including prostate, breast, and thyroid. In prostate cancer. it has been shown that CD97 is hetoerodimerizing with another GPCR, LPAR. The interaction is believed to further enhance the RHO signaling between both receptors.[7]


  1. ^ Hamann J, Eichler W, Hamann D, Kerstens HM, Poddighe PJ, Hoovers JM, Hartmann E, Strauss M, van Lier RA (Sep 1995). "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain". J Immunol 155 (4): 1942–50. PMID 7636245. 
  2. ^ Hamann J, Hartmann E, van Lier RA (Sep 1996). "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily". Genomics 32 (1): 144–7. doi:10.1006/geno.1996.0092. PMID 8786105. 
  3. ^ a b "Entrez Gene: CD97 CD97 molecule". 
  4. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  5. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  6. ^ Ward, Y., R. Lake, J. J. Yin, C. D. Heger, M. Raffeld, P. K. Goldsmith, M. Merino, K. Kelly. 2011. LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells" Cancer Res 71: 7301–7311.
  7. ^ Ward Y, Lake R, Martin P L, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng S-Y, Santoro M, Garcia-Rostan G, Kelly K,CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. Oncogene. 2012/07/16/online

Further reading[edit]

  • Mustafa T, Klonisch T, Hombach-Klonisch S, Kehlen A, Schmutzler C, Koehrle J, Gimm O, Dralle H, Hoang-Vu C (February 2004). "Expression of CD97 and CD55 in human medullary thyroid carcinomas". Int. J. Oncol. 24 (2): 285–94. doi:10.3892/ijo.24.2.285. PMID 14719104. 
  • Mustafa T, Eckert A, Klonisch T, Kehlen A, Maurer P, Klintschar M, Erhuma M, Zschoyan R, Gimm O, Dralle H, Schubert J, Hoang-Vu C (January 2005). "Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas". Cancer Epidemiol. Biomarkers Prev. 14 (1): 108–19. PMID 15668483. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.