CDC14B

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Cell division cycle 14B
Protein CDC14B PDB 1ohc.png
PDB rendering based on 1ohc.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDC14B ; CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
External IDs OMIM603505 MGI2441808 HomoloGene104197 GeneCards: CDC14B Gene
EC number 3.1.3.16, 3.1.3.48
Orthologs
Species Human Mouse
Entrez 8555 218294
Ensembl ENSG00000081377 ENSMUSG00000033102
UniProt O60729 Q6PFY9
RefSeq (mRNA) NM_001077181 NM_001122989
RefSeq (protein) NP_001070649 NP_001116461
Location (UCSC) Chr 9:
99.25 – 99.38 Mb
Chr 13:
64.19 – 64.27 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.[1][2]

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.[2]

Interactions[edit]

CDC14B has been shown to interact with p53.[3] However, this interaction has not been reported in other studies.

References[edit]

  1. ^ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem 272 (47): 29403–29406. doi:10.1074/jbc.272.47.29403. PMID 9367992. 
  2. ^ a b "Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)". 
  3. ^ Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. (UNITED STATES) 275 (4): 2410–2414. doi:10.1074/jbc.275.4.2410. ISSN 0021-9258. PMID 10644693. 

Further reading[edit]