CDC25B

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Cell division cycle 25B
Protein CDC25B PDB 1cwr.png
PDB rendering based on 1cwr.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol CDC25B
External IDs OMIM116949 MGI99701 HomoloGene41451 ChEMBL: 4804 GeneCards: CDC25B Gene
EC number 3.1.3.48
RNA expression pattern
PBB GE CDC25B 201853 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 994 12531
Ensembl ENSG00000101224 ENSMUSG00000027330
UniProt P30305 P30306
RefSeq (mRNA) NM_001287516 NM_001111075
RefSeq (protein) NP_001274445 NP_001104545
Location (UCSC) Chr 20:
3.77 – 3.79 Mb
Chr 2:
131.19 – 131.2 Mb
PubMed search [1] [2]

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.[1]

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.[2]

Interactions[edit]

CDC25B has been shown to interact with MAPK14,[3] Casein kinase 2, alpha 1,[4] CHEK1,[5] MELK,[6] Estrogen receptor alpha,[7] YWHAB,[8][9] YWHAZ,[8] YWHAH[8] and YWHAE.[8][9]

References[edit]

  1. ^ Galaktionov K, Beach D (February 1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID 1836978. 
  2. ^ "Entrez Gene: CDC25B cell division cycle 25 homolog B (S. pombe)". 
  3. ^ Bulavin, D V; Higashimoto Y; Popoff I J; Gaarde W A; Basrur V; Potapova O; Appella E; Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature (England) 411 (6833): 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986. 
  4. ^ Theis-Febvre, Nathalie; Filhol Odile; Froment Carine; Cazales Martine; Cochet Claude; Monsarrat Bernard; Ducommun Bernard; Baldin Véronique (January 2003). "Protein kinase CK2 regulates CDC25B phosphatase activity". Oncogene (England) 22 (2): 220–32. doi:10.1038/sj.onc.1206107. ISSN 0950-9232. PMID 12527891. 
  5. ^ Sanchez, Y; Wong C; Thoma R S; Richman R; Wu Z; Piwnica-Worms H; Elledge S J (September 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science (UNITED STATES) 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511. 
  6. ^ Davezac, Noélie; Baldin Véronique; Blot Joëlle; Ducommun Bernard; Tassan Jean-Pierre (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene (England) 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. ISSN 0950-9232. PMID 12400006. 
  7. ^ Ma, Z Q; Liu Z; Ngan E S; Tsai S Y (December 2001). "Cdc25B Functions as a Novel Coactivator for the Steroid Receptors". Mol. Cell. Biol. (United States) 21 (23): 8056–67. doi:10.1128/MCB.21.23.8056-8067.2001. ISSN 0270-7306. PMC 99972. PMID 11689696. 
  8. ^ a b c d Mils, V; Baldin V; Goubin F; Pinta I; Papin C; Waye M; Eychene A; Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene (ENGLAND) 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. ISSN 0950-9232. PMID 10713667. 
  9. ^ a b Conklin, D S; Galaktionov K; Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (17): 7892–6. doi:10.1073/pnas.92.17.7892. ISSN 0027-8424. PMC 41252. PMID 7644510. 

Further reading[edit]