CDC25C

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Cell division cycle 25C
Protein CDC25C PDB 3BZI.png
Rendering based on PDB 3BZI.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDC25C ; CDC25; PPP1R60
External IDs OMIM157680 MGI88350 HomoloGene1356 ChEMBL: 2378 GeneCards: CDC25C Gene
EC number 3.1.3.48
RNA expression pattern
PBB GE CDC25C 205167 s at tn.png
PBB GE CDC25C 217010 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 995 12532
Ensembl ENSG00000158402 ENSMUSG00000044201
UniProt P30307 P48967
RefSeq (mRNA) NM_001790 NM_009860
RefSeq (protein) NP_001781 NP_033990
Location (UCSC) Chr 5:
137.62 – 137.67 Mb
Chr 18:
34.73 – 34.75 Mb
PubMed search [1] [2]

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.[1]

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.[2]

Interactions[edit]

CDC25C has been shown to interact with MAPK14,[3] CHEK1,[4] PCNA,[5] PIN1,[6][7][8] PLK3[9] and NEDD4.[8]

See also[edit]

References[edit]

  1. ^ Gould KL, Moreno S, Tonks NK, Nurse P (Feb 1991). "Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase". Science 250 (4987): 1573–6. doi:10.1126/science.1703321. PMID 1703321. 
  2. ^ "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)". 
  3. ^ Bulavin, D V; Higashimoto Y; Popoff I J; Gaarde W A; Basrur V; Potapova O; Appella E; Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature (England) 411 (6833): 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986. 
  4. ^ Sanchez, Y; Wong C; Thoma R S; Richman R; Wu Z; Piwnica-Worms H; Elledge S J (Sep 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science (UNITED STATES) 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511. 
  5. ^ Kawabe, Takumi; Suganuma Masashi; Ando Tomoaki; Kimura Mayumi; Hori Haruna; Okamoto Takashi (Mar 2002). "Cdc25C interacts with PCNA at G2/M transition". Oncogene (England) 21 (11): 1717–26. doi:10.1038/sj.onc.1205229. ISSN 0950-9232. PMID 11896603. 
  6. ^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. (UNITED STATES) 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405. 
  7. ^ Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (Nov 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. (United States) 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498. 
  8. ^ a b Lu, P J; Zhou X Z; Shen M; Lu K P (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science (UNITED STATES) 283 (5406): 1325–8. doi:10.1126/science.283.5406.1325. ISSN 0036-8075. PMID 10037602. 
  9. ^ Ouyang, B; Li W; Pan H; Meadows J; Hoffmann I; Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene (ENGLAND) 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. ISSN 0950-9232. PMID 10557092. 

Further reading[edit]