CDC2L5

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Cyclin-dependent kinase 13
Identifiers
Symbols CDK13 ; CDC2L; CDC2L5; CHED; hCDK13
External IDs OMIM603309 MGI1916812 HomoloGene68359 ChEMBL: 1795192 GeneCards: CDK13 Gene
EC number 2.7.11.22, 2.7.11.23
RNA expression pattern
PBB GE CDC2L5 210965 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8621 69562
Ensembl ENSG00000065883 ENSMUSG00000041297
UniProt Q14004 Q69ZA1
RefSeq (mRNA) NM_003718 NM_001081058
RefSeq (protein) NP_003709 NP_001074527
Location (UCSC) Chr 7:
39.99 – 40.14 Mb
Chr 13:
17.72 – 17.81 Mb
PubMed search [1] [2]

Cell division cycle 2-like protein kinase 5 is an enzyme that in humans is encoded by the CDC2L5 gene.[1][2]

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. Some of the cell cycle control kinases are able to phosphorylate proteins that are important for cell differentiation and apoptosis, thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such as neurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.[2]

References[edit]

  1. ^ Lapidot-Lifson Y, Patinkin D, Prody CA, Ehrlich G, Seidman S, Ben-Aziz R, Benseler F, Eckstein F, Zakut H, Soreq H (Feb 1992). "Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis". Proc Natl Acad Sci U S A 89 (2): 579–83. doi:10.1073/pnas.89.2.579. PMC 48282. PMID 1731328. 
  2. ^ a b "Entrez Gene: CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller)". 

Further reading[edit]